George Khelashvili
Overview
Explore the profile of George Khelashvili including associated specialties, affiliations and a list of published articles.
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Articles
86
Citations
1979
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Recent Articles
1.
Marx D, Gonzalez-Hernandez A, Huynh K, Strauss A, Rico C, Siepe D, et al.
bioRxiv
. 2025 Feb;
PMID: 39975168
Despite the widespread physiological roles of beta-arrestin (β-arr) coupling in G protein-coupled receptor (GPCR) regulation, the molecular basis of GPCR/β-arr interaction has been studied primarily in monomeric family A GPCRs....
2.
Chakraborty S, Feng Z, Lee S, Alvarenga O, Panda A, Bruni R, et al.
bioRxiv
. 2024 Aug;
PMID: 39149361
Phosphatidylserine externalization on the surface of dying cells is a key signal for their recognition and clearance by macrophages and is mediated by members of the X-Kell related (Xkr) protein...
3.
Oh M, Rosa M, Xie H, Khelashvili G
Biophys J
. 2024 Jun;
123(17):2934-2955.
PMID: 38932456
Biomolecules often exhibit complex free energy landscapes in which long-lived metastable states are separated by large energy barriers. Overcoming these barriers to robustly sample transitions between the metastable states with...
4.
Doktorova M, Khelashvili G, Ashkar R, Brown M
Biophys J
. 2024 Apr;
123(9):1164.
PMID: 38679022
No abstract available.
5.
Carten J, Khelashvili G, Bidon M, Straus M, Tang T, Jaimes J, et al.
ACS Infect Dis
. 2024 Jan;
10(2):398-411.
PMID: 38270149
The SARS-CoV-1 spike glycoprotein contains a fusion peptide (FP) segment that mediates the fusion of the viral and host cell membranes. Calcium ions are thought to position the FP optimally...
6.
Menon I, Sych T, Son Y, Morizumi T, Lee J, Ernst O, et al.
J Biol Chem
. 2024 Jan;
300(2):105649.
PMID: 38237683
Class A G protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling receptors, moonlight as constitutively active phospholipid scramblases. The plasma membrane of metazoan cells is replete with GPCRs yet...
7.
Menon I, Sych T, Son Y, Morizumi T, Lee J, Ernst O, et al.
bioRxiv
. 2023 Dec;
PMID: 38045315
Class A G protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling receptors, moonlight as constitutively active phospholipid scramblases. The plasma membrane of metazoan cells is replete with GPCRs, yet...
8.
Bergman S, Cater R, Plante A, Mancia F, Khelashvili G
Nat Commun
. 2023 Jun;
14(1):3391.
PMID: 37296098
Major Facilitator Superfamily Domain containing 2 A (MFSD2A) is a transporter that is highly enriched at the blood-brain and blood-retinal barriers, where it mediates Na-dependent uptake of ω-3 fatty acids...
9.
Doktorova M, Khelashvili G, Brown M
bioRxiv
. 2023 Jun;
PMID: 37292992
Molecular dynamics simulations of lipid membranes have become increasingly impactful in biophysics because they offer atomistic resolution of structural fluctuations in relation to their functional outputs. Yet quantitative characterization of...
10.
He C, Mansilla-Soto J, Khanra N, Hamieh M, Bustos V, Paquette A, et al.
Sci Immunol
. 2023 Mar;
8(81):eadf1426.
PMID: 36867678
Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic receptors to target and lyse cancer cells. CARs bind to cell surface antigens through...