Michael T Ferdig
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Explore the profile of Michael T Ferdig including associated specialties, affiliations and a list of published articles.
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79
Citations
3234
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Recent Articles
11.
Foster G, Sievert M, Button-Simons K, Vendrely K, Romero-Severson J, Ferdig M
BMC Genomics
. 2022 Mar;
23(1):180.
PMID: 35247977
Background: The cyclical nature of gene expression in the intraerythrocytic development cycle (IDC) of the malaria parasite, Plasmodium falciparum, confounds the accurate detection of specific transcriptional differences, e.g. as provoked...
12.
Tiwari R, Checkley L, Ferdig M, Vennerstrom J, Miller M
Biometals
. 2022 Mar;
36(2):315-320.
PMID: 35229216
Despite advances in chemotherapeutic interventions for the treatment of malaria, there is a continuing need for the development of new antimalarial agents. Previous studies indicated that co-administration of chloroquine with...
13.
Zhang M, Wang C, Oberstaller J, Thomas P, Otto T, Casandra D, et al.
Nat Commun
. 2021 Jul;
12(1):4563.
PMID: 34315897
The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we...
14.
Button-Simons K, Kumar S, Carmago N, Haile M, Jett C, Checkley L, et al.
Commun Biol
. 2021 Jun;
4(1):734.
PMID: 34127785
Genetic crosses are most powerful for linkage analysis when progeny numbers are high, parental alleles segregate evenly and numbers of inbred progeny are minimized. We previously developed a novel genetic...
15.
Davis S, Singh P, Vendrely K, Shoue D, Checkley L, McDew-White M, et al.
Malar J
. 2020 Feb;
19(1):54.
PMID: 32005233
Background: Tracking and understanding artemisinin resistance is key for preventing global setbacks in malaria eradication efforts. The ring-stage survival assay (RSA) is the current gold standard for in vitro artemisinin...
16.
Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle
Li X, Kumar S, McDew-White M, Haile M, Cheeseman I, Emrich S, et al.
PLoS Genet
. 2019 Oct;
15(10):e1008453.
PMID: 31609965
Determining the genetic basis of fitness is central to understanding evolution and transmission of microbial pathogens. In human malaria parasites (Plasmodium falciparum), most experimental work on fitness has focused on...
17.
Tirrell A, Vendrely K, Checkley L, Davis S, McDew-White M, Cheeseman I, et al.
Malar J
. 2019 Aug;
18(1):295.
PMID: 31462253
Background: Competitive outcomes between co-infecting malaria parasite lines can reveal fitness disparities in blood stage growth. Blood stage fitness costs often accompany the evolution of drug resistance, with the expectation...
18.
Davis S, Button-Simons K, Bensellak T, Ahsen E, Checkley L, Foster G, et al.
Nat Biotechnol
. 2019 Jul;
37(8):848-850.
PMID: 31324891
No abstract available.
19.
Gibbons J, Button-Simons K, Adapa S, Li S, Pietsch M, Zhang M, et al.
BMC Genomics
. 2018 Nov;
19(1):849.
PMID: 30486796
Background: Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemisinin...
20.
Ghouila A, Siwo G, Domelevo Entfellner J, Panji S, Button-Simons K, Davis S, et al.
Genome Res
. 2018 Apr;
28(5):759-765.
PMID: 29650552
Scientific research plays a key role in the advancement of human knowledge and pursuit of solutions to important societal challenges. Typically, research occurs within specific institutions where data are generated...