Michael T Ferdig
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Explore the profile of Michael T Ferdig including associated specialties, affiliations and a list of published articles.
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79
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3234
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Recent Articles
1.
Sievert M, Singh P, Shoue D, Checkley L, Brenneman K, Qahash T, et al.
bioRxiv
. 2024 Nov;
PMID: 39605531
Background: Artemisinin partial resistance (ART-R) has spread throughout Southeast Asia and mutations in , the molecular marker of resistance, are widely reported in East Africa. Effective assays and robust phenotypes...
2.
Okitwi M, Shoue D, Checkley L, Orena S, Ceja F, Taremwa Y, et al.
Antimicrob Agents Chemother
. 2024 Nov;
68(12):e0118324.
PMID: 39545737
Artemisinin partial resistance (ART-R) has emerged in eastern Africa, necessitating regular surveillance of susceptibility of to artemisinins. The microscopy-based ring-stage survival assay (RSA) provides a laboratory correlate of ART-R but...
3.
Li Q, Button-Simons K, Sievert M, Chahoud E, Foster G, Meis K, et al.
Genes (Basel)
. 2024 Jun;
15(6).
PMID: 38927622
Background: Malaria results in more than 550,000 deaths each year due to drug resistance in the most lethal () species . A full genome was published in 2002, yet 44.6%...
4.
Kane J, Li X, Kumar S, Button-Simons K, Vendrely Brenneman K, Dahlhoff H, et al.
mBio
. 2024 Jun;
15(7):e0080524.
PMID: 38912775
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the () and...
5.
Kane J, Li X, Kumar S, Button-Simons K, Vendrely Brenneman K, Dahlhoff H, et al.
bioRxiv
. 2023 Sep;
PMID: 37745488
Piperaquine (PPQ) is widely used in combination with dihydroartemisinin (DHA) as a first-line treatment against malaria parasites. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the...
6.
Amambua-Ngwa A, Button-Simons K, Li X, Kumar S, Brenneman K, Ferrari M, et al.
Nat Microbiol
. 2023 May;
8(7):1213-1226.
PMID: 37169919
Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the...
7.
Pires C, Oberstaller J, Wang C, Casandra D, Zhang M, Chawla J, et al.
Microbiol Spectr
. 2023 Apr;
11(3):e0501422.
PMID: 37067430
The antimalarial activity of the frontline drug artemisinin involves generation of reactive oxygen species (ROS) leading to oxidative damage of parasite proteins. To achieve homeostasis and maintain protein quality control...
8.
Kumar S, Li X, McDew-White M, Reyes A, Delgado E, Sayeed A, et al.
Front Cell Infect Microbiol
. 2022 Jun;
12:878496.
PMID: 35711667
What genes determine growth and nutrient utilization in asexual blood-stage malaria parasites? Competition experiments between NF54, clone 3D7, a lab-adapted African parasite, and a recently isolated Asian parasite (NHP4026) reveal...
9.
Turnbull L, Button-Simons K, Agbayani N, Ferdig M
J Genet Genomics
. 2022 Apr;
49(10):965-974.
PMID: 35395422
Variation in transcript abundance can contribute to both short-term environmental response and long-term evolutionary adaptation. Most studies are designed to assess differences in mean transcription levels and do not consider...
10.
Brenneman K, Li X, Kumar S, Delgado E, Checkley L, Shoue D, et al.
iScience
. 2022 Apr;
25(4):104095.
PMID: 35372813
Classical malaria parasite genetic crosses involve isolation, genotyping, and phenotyping of progeny parasites, which is time consuming and laborious. We tested a rapid alternative approach-bulk segregant analysis (BSA)-that utilizes sequencing...