Michael S Little
Overview
Explore the profile of Michael S Little including associated specialties, affiliations and a list of published articles.
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8
Citations
250
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Recent Articles
1.
Creekmore B, Gray J, Walton W, Biernat K, Little M, Xu Y, et al.
mSystems
. 2019 Aug;
4(4).
PMID: 31455640
Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for...
2.
Little M, Ervin S, Walton W, Tripathy A, Xu Y, Liu J, et al.
Protein Sci
. 2018 Sep;
27(12):2010-2022.
PMID: 30230652
β-Glucuronidase (GUS) enzymes in the gastrointestinal tract are involved in maintaining mammalian-microbial symbiosis and can play key roles in drug efficacy and toxicity. Parabacteroides merdae GUS was identified as an...
3.
Little M, Redinbo M
Acta Crystallogr F Struct Biol Commun
. 2018 May;
74(Pt 5):268-276.
PMID: 29717993
Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and...
4.
Little M, Pellock S, Walton W, Tripathy A, Redinbo M
Proc Natl Acad Sci U S A
. 2017 Dec;
115(2):E152-E161.
PMID: 29269393
The gut microbiota harbor diverse β-glucuronidase (GUS) enzymes that liberate glucuronic acid (GlcA) sugars from small-molecule conjugates and complex carbohydrates. However, only the Enterobacteriaceae family of human gut-associated Proteobacteria maintain...
5.
Pollet R, DAgostino E, Walton W, Xu Y, Little M, Biernat K, et al.
Structure
. 2017 Jun;
25(7):967-977.e5.
PMID: 28578872
Microbiome-encoded β-glucuronidase (GUS) enzymes play important roles in human health by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of these proteins in the human GI...
6.
Wu T, Huang J, Moore P, Little M, Walton W, Fellner R, et al.
Nat Commun
. 2017 Feb;
8:14118.
PMID: 28165446
Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family member A1, BPIFA1, is a secreted innate defence protein....
7.
Walton W, Ahmad S, Little M, Kim C, Tyrrell J, Lin Q, et al.
Biochemistry
. 2016 May;
55(21):2979-91.
PMID: 27145151
SPLUNC1 is an abundantly secreted innate immune protein in the mammalian respiratory tract that exerts bacteriostatic and antibiofilm effects, binds to lipopolysaccharide (LPS), and acts as a fluid-spreading surfactant. Here,...
8.
Eldasher L, Wen X, Little M, Bircsak K, Yacovino L, Aleksunes L
Toxicology
. 2013 Feb;
306:108-13.
PMID: 23435180
The breast cancer resistance protein (Bcrp) is an efflux transporter that participates in the biliary and renal excretion of drugs and environmental chemicals. Recent evidence suggests that pharmacological activation of...