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Michael R Shortreed

Explore the profile of Michael R Shortreed including associated specialties, affiliations and a list of published articles. Areas
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Articles 83
Citations 1594
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Recent Articles
1.
Markovich S, Frey B, Scalf M, Shortreed M, Smith L
Brain Commun . 2025 Jan; 7(1):fcaf019. PMID: 39882022
Alzheimer's disease (AD) is characterized by the accumulation of protein aggregates, which are thought to be influenced by posttranslational modifications (PTMs). Dehydroamino acids (DHAAs) are rarely observed PTMs that contain...
2.
Solivais A, Boekweg H, Smith L, Noble W, Shortreed M, Payne S, et al.
bioRxiv . 2024 Nov; PMID: 39605422
The goal of proteomics is to identify and quantify peptides and proteins within a biological sample. Almost all algorithms for the identification of peptides in LC-MS/MS data employ two steps:...
3.
Bollon J, Shortreed M, Jordan B, Miller R, Jeffery E, Cavalli A, et al.
bioRxiv . 2024 Jun; PMID: 38915658
Studying protein isoforms is an essential step in biomedical research; at present, the main approach for analyzing proteins is via bottom-up mass spectrometry proteomics, which return peptide identifications, that are...
4.
Polasky D, Lu L, Yu F, Li K, Shortreed M, Smith L, et al.
Anal Bioanal Chem . 2024 Jun; 417(5):921-930. PMID: 38877149
Identification of O-glycopeptides from tandem mass spectrometry data is complicated by the near complete dissociation of O-glycans from the peptide during collisional activation and by the combinatorial explosion of possible...
5.
Carr A, Bollis N, Pavek J, Shortreed M, Smith L
Proteomics . 2024 Mar; 24(8):e2300234. PMID: 38487981
The identification of proteoforms by top-down proteomics requires both high quality fragmentation spectra and the neutral mass of the proteoform from which the fragments derive. Intact proteoform spectra can be...
6.
Yau B, Naghiloo S, Diaz-Vegas A, Carr A, van Gerwen J, Needham E, et al.
iScience . 2024 Jan; 27(1):108707. PMID: 38188515
[This corrects the article DOI: 10.1016/j.isci.2021.103099.].
7.
Millikin R, Shortreed M, Scalf M, Smith L
Methods Mol Biol . 2022 Oct; 2426:303-313. PMID: 36308694
The rapid and accurate quantification of peptides is a critical element of modern proteomics that has become increasingly challenging as proteomic data sets grow in size and complexity. We present...
8.
Miller R, Millikin R, Rolfs Z, Shortreed M, Smith L
Methods Mol Biol . 2022 Oct; 2426:35-66. PMID: 36308684
MetaMorpheus is a free and open-source software program dedicated to the comprehensive analysis of proteomic data. In bottom-up proteomics, protein samples are digested into peptides prior to chromatographic separation and...
9.
Dai Y, Millikin R, Rolfs Z, Shortreed M, Smith L
J Proteome Res . 2022 Oct; 21(11):2609-2618. PMID: 36206157
Tandem mass spectrometry (MS/MS) is widely employed for the analysis of complex proteomic samples. While protein sequence database searching and spectral library searching are both well-established peptide identification methods, each...
10.
Suddhapas K, Choi M, Shortreed M, Timperman A
J Proteome Res . 2022 Sep; 21(10):2443-2452. PMID: 36108102
The SARS-CoV-2 omicron variant presented significant challenges to the global effort to counter the pandemic. SARS-CoV-2 is predicted to remain prevalent for the foreseeable future, making the ability to identify...