Brian L Frey
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Explore the profile of Brian L Frey including associated specialties, affiliations and a list of published articles.
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46
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1118
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Recent Articles
1.
Markovich S, Frey B, Scalf M, Shortreed M, Smith L
Brain Commun
. 2025 Jan;
7(1):fcaf019.
PMID: 39882022
Alzheimer's disease (AD) is characterized by the accumulation of protein aggregates, which are thought to be influenced by posttranslational modifications (PTMs). Dehydroamino acids (DHAAs) are rarely observed PTMs that contain...
2.
Pavek J, Whitworth I, Nakayama L, Scalf M, Frey B, Smith L
J Proteome Res
. 2024 Dec;
24(1):323-332.
PMID: 39661499
Top-down proteomics, the characterization of intact proteoforms by tandem mass spectrometry, is the principal method for proteoform characterization in complex samples. Top-down proteomics relies on precursor isolation and subsequent gas-phase...
3.
Pavek J, Frey B, Frost D, Gu T, Li L, Smith L
Anal Chem
. 2023 Oct;
95(41):15245-15253.
PMID: 37791746
Top-down proteomics, the tandem mass spectrometric analysis of intact proteoforms, is the dominant method for proteoform characterization in complex mixtures. While this strategy produces detailed molecular information, it also requires...
4.
Ling Z, Noda K, Frey B, Hu M, Fok S, Smith L, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 May;
325(1):L30-L44.
PMID: 37130807
Despite recent technological advances such as ex vivo lung perfusion (EVLP), the outcome of lung transplantation remains unsatisfactory with ischemic injury being a common cause for primary graft dysfunction. New...
5.
Whitworth I, Henke K, Yang B, Scalf M, Frey B, Jarrard D, et al.
Anal Chem
. 2023 Apr;
95(18):7087-7092.
PMID: 37093976
RNA-protein interactions are key to many aspects of cellular homeostasis and their identification is important to understanding cellular function. Multiple strategies have been developed for the RNA-centric characterization of RNA-protein...
6.
Miller R, Knoener R, Benner B, Frey B, Scalf M, Shortreed M, et al.
J Proteome Res
. 2022 Feb;
21(4):993-1001.
PMID: 35192358
Human immunodeficiency virus type 1 (HIV-1) remains a deadly infectious disease despite existing antiretroviral therapies. A comprehensive understanding of the specific mechanisms of viral infectivity remains elusive and currently limits...
7.
Carr A, Frey B, Scalf M, Cesnik A, Rolfs Z, Pike K, et al.
J Proteome Res
. 2022 Jan;
21(2):410-419.
PMID: 35073098
Interpreting proteomics data remains challenging due to the large number of proteins that are quantified by modern mass spectrometry methods. Weighted gene correlation network analysis (WGCNA) can identify groups of...
8.
Rolfs Z, Frey B, Shi X, Kawai Y, Smith L, Welham N
Nat Commun
. 2021 Nov;
12(1):6778.
PMID: 34836951
Protein turnover is critical to cellular physiology as well as to the growth and maintenance of tissues. The unique synthesis and degradation rates of each protein help to define tissue...
9.
Shortreed M, Millikin R, Liu L, Rolfs Z, Miller R, Schaffer L, et al.
J Proteome Res
. 2021 Mar;
20(4):1997-2004.
PMID: 33683901
MetaMorpheus is a free, open-source software program for the identification of peptides and proteoforms from data-dependent acquisition tandem MS experiments. There is inherent uncertainty in these assignments for several reasons,...
10.
Cesnik A, Miller R, Ibrahim K, Lu L, Millikin R, Shortreed M, et al.
J Proteome Res
. 2020 Sep;
20(4):1826-1834.
PMID: 32967423
Proteoforms are the workhorses of the cell, and subtle differences between their amino acid sequences or post-translational modifications (PTMs) can change their biological function. To most effectively identify and quantify...