Michael R Blackburn
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Explore the profile of Michael R Blackburn including associated specialties, affiliations and a list of published articles.
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144
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6532
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Recent Articles
11.
Liu H, Adebiyi M, Liu R, Song A, Manalo J, Wen Y, et al.
Blood Adv
. 2018 Aug;
2(15):1957-1968.
PMID: 30097462
Although excessive plasma adenosine is detrimental in sickle cell disease (SCD), the molecular mechanism underlying elevated circulating adenosine remains unclear. Here we report that the activity of soluble CD73, an...
12.
Kiers D, Wielockx B, Peters E, van Eijk L, Gerretsen J, John A, et al.
EBioMedicine
. 2018 Jul;
33:144-156.
PMID: 29983349
Hypoxia and inflammation are closely intertwined phenomena. Critically ill patients often suffer from systemic inflammatory conditions and concurrently experience short-lived hypoxia. We evaluated the effects of short-term hypoxia on systemic...
13.
Huang J, Weng T, Ko J, Chen N, Xiang Y, Volcik K, et al.
Biochem Biophys Res Commun
. 2018 Jun;
503(2):856-862.
PMID: 29928883
Background: Non-small cell lung cancer (NSCLC) is a life-threatening disease that has a poor prognosis and low survival rate. Cleavage factor Im 25 (CFIm25) is a RNA-binding protein that if...
14.
Mertens T, Hanmandlu A, Tu L, Phan C, Collum S, Chen N, et al.
Front Physiol
. 2018 Jun;
9:555.
PMID: 29910735
Pulmonary hypertension (PH) is a devastating and progressive disease characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and remodeling of the lung vasculature. Adenosine signaling through the...
15.
Karmouty-Quintana H, Molina J, Philip K, Bellocchi C, Gudenkauf B, Wu M, et al.
Arthritis Rheumatol
. 2018 May;
70(10):1673-1684.
PMID: 29771006
Objective: Systemic sclerosis (SSc; scleroderma) is a chronic disease that affects the skin and various internal organs. Dermal fibrosis is a major component of this disease. The mechanisms that promote...
16.
Hoegl S, Burns N, Angulo M, Francis D, Osborne C, Mills T, et al.
Physiol Rep
. 2018 Mar;
6(6):e13648.
PMID: 29595879
Severe acute respiratory distress syndrome (ARDS) presents typically with an initializing event, followed by the need for mechanical ventilation. Most animal models of ALI are limited by the fact that...
17.
Xiang Y, Ye Y, Lou Y, Yang Y, Cai C, Zhang Z, et al.
J Natl Cancer Inst
. 2017 Nov;
110(4):379-389.
PMID: 29106591
Background: Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several human diseases. However, the functional consequences of APA in...
18.
Neudecker V, Brodsky K, Clambey E, Schmidt E, Packard T, Davenport B, et al.
Sci Transl Med
. 2017 Sep;
9(408).
PMID: 28931657
Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung...
19.
Muller T, Fay S, Vieira R, Karmouty-Quintana H, Cicko S, Ayata C, et al.
Front Immunol
. 2017 Sep;
8:1028.
PMID: 28878780
Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor subtypes P2Y and P2X in fibrotic lung...
20.
Li H, Karmouty-Quintana H, Chen N, Mills T, Molina J, Blackburn M, et al.
Pediatr Res
. 2017 Aug;
PMID: 28832580
BackgroundHyperoxic lung injury is characterized by cellular damage from high oxygen concentrations that lead to an inflammatory response and it disrupts normal alveolarization in the developing newborn lung. Adenosine is...