Michael Pack
Overview
Explore the profile of Michael Pack including associated specialties, affiliations and a list of published articles.
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48
Citations
1468
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Recent Articles
11.
Waisbourd-Zinman O, Koh H, Tsai S, Lavrut P, Dang C, Zhao X, et al.
Hepatology
. 2016 Apr;
64(3):880-93.
PMID: 27081925
Unlabelled: Biliary atresia, the most common indication for pediatric liver transplantation, is a fibrotic disease of unknown etiology affecting the extrahepatic bile ducts of newborns. The recently described toxin biliatresone...
12.
Abrams J, Einhorn Z, Seiler C, Zong A, Sweeney H, Pack M
Dis Model Mech
. 2016 Feb;
9(5):529-40.
PMID: 26893369
Smooth muscle contraction is controlled by the regulated activity of the myosin heavy chain ATPase (Myh11). Myh11 mutations have diverse effects in the cardiovascular, digestive and genitourinary systems in humans...
13.
Koo K, Waisbourd-Zinman O, Wells R, Pack M, Porter J
Chem Res Toxicol
. 2015 Dec;
29(2):142-9.
PMID: 26713899
In our previous work, we identified a natural toxin, biliatresone, from Dysphania glomulifera and D. littoralis, endemic plants associated with outbreaks of biliary atresia in Australian neonatal livestock. Biliatresone is...
14.
Koo K, Lorent K, Gong W, Windsor P, Whittaker S, Pack M, et al.
Chem Res Toxicol
. 2015 Jul;
28(8):1519-21.
PMID: 26175131
We identified a reactive natural toxin, biliatresone, from Dysphania glomulifera and D. littoralis collected in Australia that produces extrahepatic biliary atresia in a zebrafish model. Three additional isoflavonoids, including the...
15.
Lorent K, Gong W, Koo K, Waisbourd-Zinman O, Karjoo S, Zhao X, et al.
Sci Transl Med
. 2015 May;
7(286):286ra67.
PMID: 25947162
Biliary atresia (BA) is a rapidly progressive and destructive fibrotic disorder of unknown etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest that an environmental factor, such as...
16.
Pack M
Nat Rev Gastroenterol Hepatol
. 2015 May;
12(6):318-20.
PMID: 25942704
A genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing...
17.
Wilkins B, Gong W, Pack M
Gene Expr Patterns
. 2014 Jan;
14(2):62-8.
PMID: 24394404
Heritable and acquired biliary disorders are an important cause of acute and chronic human liver disease. Biliary development and physiology have been studied extensively in rodent models and more recently,...
18.
Wilkins B, Lorent K, Matthews R, Pack M
PLoS One
. 2013 Oct;
8(10):e77670.
PMID: 24147052
North American Indian Childhood Cirrhosis (NAIC) is a rare, autosomal recessive, progressive cholestatic disease of infancy affecting the Cree-Ojibway first Nations of Quebec. All NAIC patients are homozygous for a...
19.
Valvezan A, Huang J, Lengner C, Pack M, Klein P
Dis Model Mech
. 2013 Oct;
7(1):63-71.
PMID: 24092877
Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt-β-catenin...
20.
Wilkins B, Pack M
Compr Physiol
. 2013 Jul;
3(3):1213-30.
PMID: 23897685
The liver performs a large number of essential synthetic and regulatory functions that are acquired during fetal development and persist throughout life. Their disruption underlies a diverse group of heritable...