Michael P Maher
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Explore the profile of Michael P Maher including associated specialties, affiliations and a list of published articles.
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19
Citations
245
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Recent Articles
1.
Liu Y, Ma J, DesJarlais R, Hagan R, Rech J, Liu C, et al.
Sci Rep
. 2024 Jan;
14(1):2320.
PMID: 38282035
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants...
2.
Hagan R, Rex E, Woody D, Milewski M, Glaza T, Maher M, et al.
Sci Rep
. 2021 Jan;
11(1):456.
PMID: 33432098
L-type calcium channels (LTCCs) are highly expressed in the heart and brain and are critical for cardiac and neuronal functions. LTCC-blocking drugs have a long and successful record in the...
3.
Wu N, Nishioka W, Derecki N, Maher M
Sci Rep
. 2019 Sep;
9(1):12692.
PMID: 31481721
Measurement of intracellular calcium in live cells is a key component of a wide range of basic life science research, and crucial for many high-throughput assays used in modern drug...
4.
Savall B, Wu D, Swanson D, Seierstad M, Wu N, Vives Martinez J, et al.
ACS Med Chem Lett
. 2019 Mar;
10(3):267-272.
PMID: 30891124
This report discloses the discovery and characterization of imidazo[1,2-]pyrazines and pyrazolo[1,5-]pyrimidines as selective negative modulators of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) associated with transmembrane AMPAR regulatory protein γ-8. Imidazopyrazine was initially identified...
5.
Ravula S, Savall B, Wu N, Lord B, Coe K, Wang K, et al.
ACS Med Chem Lett
. 2018 Aug;
9(8):821-826.
PMID: 30128074
Glutamate mediates fast excitatory neurotransmission via ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The trafficking and gating properties of AMPA receptors (AMPARs) can be amplified by transmembrane AMPAR regulatory proteins (TARPs), which...
6.
Maher M, Matta J, Gu S, Seierstad M, Bredt D
Neuron
. 2017 Dec;
96(5):989-1001.
PMID: 29216460
Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins...
7.
Maher M, Ameriks M, Savall B, Carruthers N, Lovenberg T
J Pharmacol Exp Ther
. 2016 Aug;
358(3):527.
PMID: 27528545
No abstract available.
8.
Maher M, Wu N, Ravula S, Ameriks M, Savall B, Liu C, et al.
J Pharmacol Exp Ther
. 2016 Mar;
357(2):394-414.
PMID: 26989142
Members of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA) subtype of ionotropic glutamate receptors mediate the majority of fast synaptic transmission within the mammalian brain and spinal cord, representing attractive targets for therapeutic...
9.
Edwards W, Fung-Leung W, Huang C, Chi E, Wu N, Liu Y, et al.
J Biol Chem
. 2014 Jun;
289(33):22704-22714.
PMID: 24939846
Ion channels are an attractive class of drug targets, but progress in developing inhibitors for therapeutic use has been limited largely due to challenges in identifying subtype selective small molecules....
10.
Maher M, Bhattacharya A, Ao H, Swanson N, Wu N, Freedman J, et al.
Eur J Pharmacol
. 2011 May;
663(1-3):40-50.
PMID: 21575625
As an integrator of multiple nociceptive and/or inflammatory stimuli, TRPV1 is an attractive therapeutic target for the treatment of various painful disorders. Several TRPV1 antagonists have been advanced into clinical...