Anindya Bhattacharya
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Explore the profile of Anindya Bhattacharya including associated specialties, affiliations and a list of published articles.
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92
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2276
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Recent Articles
1.
Mammoliti O, Carbajo R, Perez-Benito L, Yu X, Prieri M, Bontempi L, et al.
J Med Chem
. 2025 Feb;
68(4):4848-4887.
PMID: 39932543
NLRP3 is a danger sensor protein responsible for inflammasome activation. This leads to pro-inflammatory cytokines release, like IL-1β, and pyroptosis, a regulated cell death. Mounting evidence associates excessive NLRP3 activation...
2.
Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, et al.
Theranostics
. 2025 Jan;
15(4):1399-1419.
PMID: 39886340
Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent...
3.
Schoellerman J, Lord B, Bhattacharya A, Stenne B, Wall J, Rech J, et al.
J Neurochem
. 2024 May;
168(9):2654-2670.
PMID: 38770633
Here, we describe the characterization of a radioligand selective for GluN2B-containing NMDA receptors, 3-[H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone ([H]-JNJ- GluN2B-5). In rat cortical membranes, the compound bound to a single site, and the...
4.
Mamad O, Heiland M, Lindner A, Hill T, Ronroy R, Rentrup K, et al.
Front Pharmacol
. 2024 Jan;
14:1308478.
PMID: 38259288
There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the...
5.
Biltz R, Swanson S, Draime N, Davis A, Yin W, Goodman E, et al.
Brain Behav Immun
. 2023 Nov;
115:356-373.
PMID: 37914101
Chronic stress is linked to increased anxiety. Repeated social defeat (RSD) in mice causes anxiety that is dependent on activated neurons, reactive microglia, and accumulation of monocytes in the brain....
6.
Zell V, Teuns G, Needham A, Mukherjee S, Roscoe N, Le M, et al.
J Pharmacol Exp Ther
. 2023 Sep;
387(2):226-234.
PMID: 37679045
The type-5 muscarinic acetylcholine receptor (mAChR, M) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area and substantia nigra pars compacta; therefore, they are ideally located...
7.
Smith J, Menendez Mendez A, Alves M, Parras A, Conte G, Bhattacharya A, et al.
Br J Pharmacol
. 2023 Jan;
180(13):1710-1729.
PMID: 36637008
Background And Purpose: Neonatal seizures represent a clinical emergency. However, current anti-seizure medications fail to resolve seizures in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver of...
8.
Morgan J, Moreno O, Alves M, Baz Z, Menendez Mendez A, Leister H, et al.
Epilepsia
. 2022 Dec;
64(2):511-523.
PMID: 36507708
Objective: The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding to extracellularly released adenosine triphosphate. Expression of the P2X7R is increased in the brain in experimental and human...
9.
He Y, Taylor N, Yao X, Bhattacharya A
Sci Rep
. 2021 May;
11(1):10447.
PMID: 34001933
Microglia, CNS resident innate immune cells, respond strongly to activation of TLR3 and TLR4, which recognize viral dsRNA poly(I:C) and bacterial endotoxin LPS, respectively. However, few studies have thoroughly and...
10.
Rosenthal S, Gerasimova A, Ma C, Li H, Grupe A, Chong H, et al.
PLoS One
. 2021 Apr;
16(4):e0243683.
PMID: 33909614
Identification of genomic mutations by molecular testing plays an important role in diagnosis, prognosis, and treatment of myeloid neoplasms. Next-generation sequencing (NGS) is an efficient method for simultaneous detection of...