Michael P Gantier
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Explore the profile of Michael P Gantier including associated specialties, affiliations and a list of published articles.
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77
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2749
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Recent Articles
1.
Guanizo A, Luong Q, Jayasekara W, de Geus E, Inampudi C, Xue V, et al.
Nat Immunol
. 2024 Nov;
25(12):2259-2269.
PMID: 39572642
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an overall survival rate of ~5%. The transcription factor signal transducer and activator...
2.
Ellyard J, Gantier M
Immunol Cell Biol
. 2024 Jul;
102(8):651-654.
PMID: 38981619
UNC93B1 is essential for the stability and endosomal trafficking of nucleic-acid sensing Toll-like receptors (TLRs) including TLR7 and TLR8. Increased TLR7 responses are associated with lupus autoimmunity in both mice...
3.
El-Mortada F, Landelouci K, Bertrand-Perron S, Aube F, Poirier A, Bidias A, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 37993259
Platelets display unexpected roles in immune and coagulation responses. Emerging evidence suggests that STING is implicated in hypercoagulation. STING is an adaptor protein downstream of the DNA sensor cyclic GMP-AMP...
4.
Bichet M, Adderley J, Avellaneda-Franco L, Magnin-Bougma I, Torriero-Smith N, Gearing L, et al.
PLoS Biol
. 2023 Oct;
21(10):e3002341.
PMID: 37883333
There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these bacteriophages may have on mammalian...
5.
Ullah T, Johansen M, Balka K, Ambrose R, Gearing L, Roest J, et al.
Nat Commun
. 2023 Sep;
14(1):5666.
PMID: 37723181
TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε),...
6.
Sapkota S, Gantier M
Methods Mol Biol
. 2023 Jun;
2691:225-234.
PMID: 37355549
A growing body of preclinical evidence has led to the hypothesis that human Toll-like receptor 8 (hTLR8) activation in the tumor microenvironment (TME) could have potent anticancer effects through its...
7.
Ullah T, Balka K, Ambrose R, Pepin G, Wilce M, Wilce J, et al.
mBio
. 2022 Aug;
13(4):e0206422.
PMID: 35924852
Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in...
8.
Steiner A, Hrovat-Schaale K, Prigione I, Yu C, Laohamonthonkul P, Harapas C, et al.
Nat Commun
. 2022 Apr;
13(1):2321.
PMID: 35484149
Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha causes COPA syndrome and is associated with...
9.
Brown G, Canete P, Wang H, Medhavy A, Bones J, Roco J, et al.
Nature
. 2022 Apr;
605(7909):349-356.
PMID: 35477763
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease, evidence of lupus-causing TLR7 gene variants is lacking. Here we describe human...
10.
Al-Asmari S, Rajapakse A, Ullah T, Pepin G, Croft L, Gantier M
Front Cell Dev Biol
. 2022 Jan;
9:709618.
PMID: 35087822
Activation of the STING pathway upon genotoxic treatment of cancer cells has been shown to lead to anti-tumoral effects, mediated through the acute production of interferon (IFN)-β. Conversely, the pathway...