Michael P Coleman
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Explore the profile of Michael P Coleman including associated specialties, affiliations and a list of published articles.
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103
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4284
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Recent Articles
1.
Antoniou C, Loreto A, Gilley J, Merlini E, Orsomando G, Coleman M
Mol Neurobiol
. 2024 Oct;
62(3):3903-3917.
PMID: 39352636
Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is an endogenous axon survival factor that maintains axon health by blocking activation of the downstream pro-degenerative protein SARM1 (sterile alpha and TIR motif containing...
2.
Tribble J, Joe M, Varricchio C, Otmani A, Canovai A, Habchi B, et al.
Nat Commun
. 2024 Sep;
15(1):8143.
PMID: 39289370
No abstract available.
3.
Tribble J, Joe M, Varricchio C, Otmani A, Canovai A, Habchi B, et al.
Nat Commun
. 2024 Jul;
15(1):6256.
PMID: 39048544
Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme,...
4.
Loreto A, Merlini E, Coleman M
Eye (Lond)
. 2024 Mar;
38(10):1802-1809.
PMID: 38538779
Programmed axon death is a druggable pathway of axon degeneration that has garnered considerable interest from pharmaceutical companies as a promising therapeutic target for various neurodegenerative disorders. In this review,...
5.
Cirilli I, Amici A, Gilley J, Coleman M, Orsomando G
Molecules
. 2024 Feb;
29(4).
PMID: 38398599
Here, we report an adapted protocol using the Promega NAD/NADH-Glo™ Assay kit. The assay normally allows quantification of trace amounts of both oxidized and reduced forms of nicotinamide adenine dinucleotide...
6.
Yang S, Niou Z, Enriquez A, LaMar J, Huang J, Ling K, et al.
Mol Neurodegener
. 2024 Jan;
19(1):13.
PMID: 38282024
Background: Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide...
7.
Mutschler C, Fazal S, Schumacher N, Loreto A, Coleman M, Arthur-Farraj P
J Cell Sci
. 2023 Aug;
136(18).
PMID: 37642648
Myelinating Schwann cell (SC)-dorsal root ganglion (DRG) neuron cocultures are an important technique for understanding cell-cell signalling and interactions during peripheral nervous system (PNS) myelination, injury, and regeneration. Although methods...
8.
Yang S, Niou Z, Enriquez A, LaMar J, Huang J, Ling K, et al.
Res Sq
. 2023 Jun;
PMID: 37292715
Background: Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide...
9.
Fazal S, Mutschler C, Chen C, Turmaine M, Chen C, Hsueh Y, et al.
Front Cell Neurosci
. 2023 Apr;
17:1158388.
PMID: 37091921
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in a variety of disorders of the peripheral (PNS)...
10.
Loreto A, Antoniou C, Merlini E, Gilley J, Coleman M
Neurosci Res
. 2023 Jan;
197:18-24.
PMID: 36657725
The past 20 years of research on axon degeneration has revealed fine details on how NAD biology controls axonal survival. Extensive data demonstrate that the NAD precursor NMN binds to...