Michael Niederweis
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Explore the profile of Michael Niederweis including associated specialties, affiliations and a list of published articles.
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108
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4430
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Recent Articles
1.
Earp J, Garaeva A, Meikle V, Niederweis M, Seeger M
Nat Commun
. 2025 Feb;
16(1):1934.
PMID: 39994240
To replicate and cause disease, Mycobacterium tuberculosis secretes siderophores called mycobactins to scavenge iron from the human host. Two closely related transporters, MmpL4 and MmpL5, are required for mycobactin secretion...
2.
Lokareddy R, Hou C, Forti F, Iglesias S, Li F, Pavlenok M, et al.
Nat Commun
. 2024 Oct;
15(1):8482.
PMID: 39353939
DEV is an obligatory lytic Pseudomonas phage of the N4-like genus, recently reclassified as Schitoviridae. The DEV genome encodes 91 ORFs, including a 3398 amino acid virion-associated RNA polymerase (vRNAP)....
3.
Cingolani G, Lokareddy R, Hou C, Forti F, Iglesias S, Li F, et al.
Res Sq
. 2024 Mar;
PMID: 38463957
DEV is an obligatory lytic phage of the N4-like genus, recently reclassified as . The DEV genome encodes 91 ORFs, including a 3,398 amino acid virion-associated RNA polymerase. Here, we...
4.
Pavlenok M, Nair R, Hendrickson R, Niederweis M
Protein Sci
. 2024 Feb;
33(3):e4912.
PMID: 38358254
Outer membrane proteins perform essential functions in uptake and secretion processes in bacteria. MspA is an octameric channel protein in the outer membrane of Mycobacterium smegmatis and is structurally distinct...
5.
Meikle V, Zhang L, Niederweis M
Antimicrob Agents Chemother
. 2023 Sep;
67(10):e0162922.
PMID: 37676015
Drug-resistant is a worldwide health-care problem rendering current tuberculosis (TB) drugs ineffective. Drug efflux is an important mechanism in bacterial drug resistance. The MmpL4 and MmpL5 transporters form functionally redundant...
6.
Shallom S, Tettelin H, Chandrasekaran P, Park I, Agrawal S, Arora K, et al.
Virulence
. 2023 May;
14(1):2215602.
PMID: 37221835
Background: subspecies ( ) is increasingly recognized as an emerging bacterial pathogen, particularly in cystic fibrosis (CF) patients and CF centres' respiratory outbreaks. We characterized genomic and phenotypic changes in...
7.
Donegan R, Fu Y, Copeland J, Idga S, Brown G, Hale O, et al.
Microbiol Spectr
. 2022 Sep;
10(5):e0360422.
PMID: 36169423
Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it...
8.
Zhang L, Kent J, Whitaker M, Young D, Herrmann D, Aleshin A, et al.
Nat Commun
. 2022 Apr;
13(1):2255.
PMID: 35474308
Iron is essential for growth of Mycobacterium tuberculosis, the causative agent of tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called mycobactins and carboxymycobactins. Here, we...
9.
Pavlenok M, Yu L, Herrmann D, Wanunu M, Niederweis M
Biophys J
. 2022 Feb;
121(5):742-754.
PMID: 35101416
Transmembrane protein channels enable fast and highly sensitive detection of single molecules. Nanopore sequencing of DNA was achieved using an engineered Mycobacterium smegmatis porin A (MspA) in combination with a...
10.
Spencer B, Tak U, Mendonca J, Nagao P, Niederweis M, Doran K
PLoS Pathog
. 2021 Dec;
17(12):e1010121.
PMID: 34871327
Type VII secretion systems (T7SS) have been identified in Actinobacteria and Firmicutes and have been shown to secrete effector proteins with functions in virulence, host toxicity, and/or interbacterial killing in...