Michael Mulleder
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Explore the profile of Michael Mulleder including associated specialties, affiliations and a list of published articles.
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64
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2119
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Recent Articles
11.
Teyssonniere E, Trebulle P, Muenzner J, Loegler V, Ludwig D, Amari F, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(19):e2319211121.
PMID: 38696467
Gene expression varies between individuals and corresponds to a key step linking genotypes to phenotypes. However, our knowledge regarding the species-wide genetic control of protein abundance, including its dependency on...
12.
Tengolics R, Szappanos B, Mulleder M, Kalapis D, Grezal G, Sajben C, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(11):e2313354121.
PMID: 38457520
Cellular metabolism evolves through changes in the structure and quantitative states of metabolic networks. Here, we explore the evolutionary dynamics of metabolic states by focusing on the collection of metabolite...
13.
TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice
Kespohl M, Goetzke C, Althof N, Bredow C, Kelm N, Pinkert S, et al.
Arterioscler Thromb Vasc Biol
. 2024 Feb;
44(4):843-865.
PMID: 38385286
Background: Accumulating evidence implicates the activation of G-protein-coupled PARs (protease-activated receptors) by coagulation proteases in the regulation of innate immune responses. Methods: Using mouse models with genetic alterations of the...
14.
Radke J, Meinhardt J, Aschman T, Chua R, Farztdinov V, Lukassen S, et al.
Nat Neurosci
. 2024 Feb;
27(3):409-420.
PMID: 38366144
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the mechanisms that contribute to...
15.
Bredow C, Thery F, Wirth E, Ochs S, Kespohl M, Kleinau G, et al.
Cardiovasc Res
. 2024 Feb;
120(6):644-657.
PMID: 38309955
Aims: Virus infection triggers inflammation and, may impose nutrient shortage to the heart. Supported by type I interferon (IFN) signalling, cardiomyocytes counteract infection by various effector processes, with the IFN-stimulated...
16.
White M, Sinn L, Jones D, de Folter J, Kaur Aulakh S, Wang Z, et al.
Nat Biomed Eng
. 2023 Jul;
8(3):233-247.
PMID: 37474612
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the...
17.
Scheibenbogen C, Bellmann-Strobl J, Heindrich C, Wittke K, Stein E, Franke C, et al.
Front Med (Lausanne)
. 2023 Jul;
10:1194754.
PMID: 37396922
The sequela of COVID-19 include a broad spectrum of symptoms that fall under the umbrella term post-COVID-19 condition or syndrome (PCS). Immune dysregulation, autoimmunity, endothelial dysfunction, viral persistence, and viral...
18.
Szyrwiel L, Gille C, Mulleder M, Demichev V, Ralser M
Proteomics
. 2023 Jun;
24(1-2):e2300100.
PMID: 37287406
Increased throughput in proteomic experiments can improve accessibility of proteomic platforms, reduce costs, and facilitate new approaches in systems biology and biomedical research. Here we propose combination of analytical flow...
19.
Messner C, Demichev V, Muenzner J, Aulakh S, Barthel N, Rohl A, et al.
Cell
. 2023 Apr;
186(9):2018-2034.e21.
PMID: 37080200
Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in...
20.
Talwar D, Miller C, Grossmann J, Szyrwiel L, Schwecke T, Demichev V, et al.
Nat Metab
. 2023 Apr;
5(4):660-676.
PMID: 37024754
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid inactivation of the enzyme. Here we show that...