Jakob Vowinckel
Overview
Explore the profile of Jakob Vowinckel including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
981
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Recent Articles
1.
Mallardo D, Fordellone M, White A, Vowinckel J, Bailey M, Sparano F, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273294
Resistance biomarkers are needed to identify patients with advanced melanoma obtaining a response to ICI treatment and developing resistance later. We searched a combination of molecular signatures of response to...
2.
Topriceanu C, Alfarih M, Hughes A, Shiwani H, Chan F, Mohiddin S, et al.
Acta Myol
. 2023 Dec;
42(2-3):43-52.
PMID: 38090549
Lamins A/C (encoded by gene) can lead to dilated cardiomyopathy (DCM). This pilot study sought to explore the postgenomic phenotype of end-stage lamin heart disease. Consecutive patients with end-stage lamin...
3.
Calandria J, Bhattacharjee S, Kala-Bhattacharjee S, Mukherjee P, Feng Y, Vowinckel J, et al.
Cell Death Dis
. 2023 Dec;
14(12):819.
PMID: 38086796
The thioredoxin (TXN) system is an NADPH + H/FAD redox-triggered effector that sustains homeostasis, bioenergetics, detoxifying drug networks, and cell survival in oxidative stress-related diseases. Elovanoid (ELV)-N34 is an endogenously...
4.
Marshall J, Peshkin B, Yoshino T, Vowinckel J, Danielsen H, Melino G, et al.
Oncologist
. 2022 Apr;
27(4):272-284.
PMID: 35380712
Within the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from...
5.
Vowinckel J, Hartl J, Marx H, Kerick M, Runggatscher K, Keller M, et al.
Nat Metab
. 2021 Nov;
3(11):1521-1535.
PMID: 34799698
Eukaryotic cells can survive the loss of their mitochondrial genome, but consequently suffer from severe growth defects. 'Petite yeasts', characterized by mitochondrial genome loss, are instrumental for studying mitochondrial function...
6.
Li J, Rinnerthaler M, Hartl J, Weber M, Karl T, Breitenbach-Koller H, et al.
G3 (Bethesda)
. 2020 Oct;
10(12):4637-4648.
PMID: 33093184
A yeast deletion mutation in the nuclear-encoded gene, , which codes for a mitochondrial ribosomal protein, led to slow growth on glucose, the inability to grow on glycerol or ethanol,...
7.
Fong S, Handyside B, Sihn C, Liu S, Zhang L, Xie L, et al.
Mol Ther Methods Clin Dev
. 2020 Aug;
18:620-630.
PMID: 32775496
Adeno-associated virus 5 (AAV5)-human factor VIII-SQ (hFVIII-SQ; valoctocogene roxaparvovec) is an AAV-mediated product under evaluation for treatment of severe hemophilia A, which contains a B-domain-deleted hFVIII (hFVIII-SQ) transgene and a...
8.
Olin-Sandoval V, Yu J, Miller-Fleming L, Alam M, Kamrad S, Correia-Melo C, et al.
Nature
. 2019 Aug;
572(7768):249-253.
PMID: 31367038
Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants. Central to the stress...
9.
Gossmann T, Shanmugasundram A, Borno S, Duvaux L, Lemaire C, Kuhl H, et al.
Curr Biol
. 2019 May;
29(10):1712-1720.e7.
PMID: 31080084
Some species responded successfully to prehistoric changes in climate [1, 2], while others failed to adapt and became extinct [3]. The factors that determine successful climate adaptation remain poorly understood....
10.
Zelezniak A, Vowinckel J, Capuano F, Messner C, Demichev V, Polowsky N, et al.
Cell Syst
. 2018 Sep;
7(3):269-283.e6.
PMID: 30195436
A challenge in solving the genotype-to-phenotype relationship is to predict a cell's metabolome, believed to correlate poorly with gene expression. Using comparative quantitative proteomics, we found that differential protein expression...