Alastair R Hawkins
Overview
Explore the profile of Alastair R Hawkins including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
51
Citations
618
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rodriguez A, Maneiro M, Lence E, Otero J, van Raaij M, Thompson P, et al.
Front Mol Biosci
. 2023 Feb;
10:1111598.
PMID: 36762206
Irreversible inhibition of the enzyme type I dehydroquinase (DHQ1), a promising target for anti-virulence drug development, has been explored by enhancing the electrophilicity of specific positions of the ligand towards...
2.
Lence E, Maneiro M, Sanz-Gaitero M, van Raaij M, Thompson P, Hawkins A, et al.
Chemistry
. 2020 Apr;
26(36):8035-8044.
PMID: 32259333
Disabling the bacterial capacity to cause infection is an innovative approach that has attracted significant attention to fight against superbugs. A relevant target for anti-virulence drug discovery is the type...
3.
Basle A, Hewitt L, Koh A, Lamb H, Thompson P, Burgess J, et al.
Nucleic Acids Res
. 2017 Nov;
46(1):473-484.
PMID: 29165717
Bacterial biofilms are a complex architecture of cells that grow on moist interfaces, and are held together by a molecular glue of extracellular proteins, sugars and nucleic acids. Biofilms are...
4.
Peon A, Robles A, Blanco B, Convertino M, Thompson P, Hawkins A, et al.
ChemMedChem
. 2017 Aug;
12(18):1512-1524.
PMID: 28791799
A multidisciplinary approach was used to identify and optimize a quinazolinedione-based ligand that would decrease the flexibility of the substrate-covering loop (catalytic loop) of the type II dehydroquinase from Helicobacter...
5.
Wilkinson D, Wang H, Habgood A, Lamb H, Thompson P, Hawkins A, et al.
Arthritis Rheumatol
. 2017 May;
69(8):1601-1611.
PMID: 28464560
Objective: To assess the ability of matriptase, a type II transmembrane serine proteinase, to promote aggrecan loss from the cartilage of patients with osteoarthritis (OA) and to determine whether its...
6.
Prado V, Lence E, Thompson P, Hawkins A, Gonzalez-Bello C
Chemistry
. 2016 Oct;
22(50):17988-18000.
PMID: 27699905
Shikimate kinase (SK), the fifth enzyme of the aromatic amino acid biosynthesis, is a recognized target for antibiotic drug discovery. The potential of the distinct dynamic apolar gap, which isolates...
7.
Prado V, Lence E, Maneiro M, Vazquez-Ucha J, Beceiro A, Thompson P, et al.
J Med Chem
. 2016 May;
59(11):5471-87.
PMID: 27191386
The large conformational changes observed by Molecular Dynamics simulation studies on the product release in the LID and shikimic acid binding (SB) domains of the shikimate kinase (SK) enzyme have...
8.
Rogowski A, Briggs J, Mortimer J, Tryfona T, Terrapon N, Lowe E, et al.
Nat Commun
. 2016 Feb;
7:10705.
PMID: 26848059
No abstract available.
9.
Prado V, Lence E, Vallejo J, Beceiro A, Thompson P, Hawkins A, et al.
Chemistry
. 2016 Jan;
22(8):2758-68.
PMID: 26797764
The phosphoryl-transfer mechanism of shikimate kinase from Mycobacterium tuberculosis and Helicobacter pylori, which is an attractive target for antibiotic drug discovery, has been studied by 1D (1)H and (31)P NMR...
10.
Gonzalez-Bello C, Tizon L, Lence E, Otero J, van Raaij M, Martinez-Guitian M, et al.
J Am Chem Soc
. 2015 Jul;
137(29):9333-43.
PMID: 26148116
The first example of an ammonium derivative that causes a specific modification of the active site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for...