Michael K Pugsley
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Explore the profile of Michael K Pugsley including associated specialties, affiliations and a list of published articles.
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82
Citations
554
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Recent Articles
21.
Authier S, Abernathy M, Correll K, Chui R, Dalton J, Foley C, et al.
Int J Toxicol
. 2020 May;
39(4):274-293.
PMID: 32406289
Introduction: The Safety Pharmacology Society (SPS) conducted a membership survey to examine industry practices related mainly to cardiovascular (CV) safety pharmacology (SP). Methods: Questions addressed nonclinical study design, data analysis...
22.
Prior H, Baldrick P, Beken S, Booler H, Bower N, Brooker P, et al.
Regul Toxicol Pharmacol
. 2020 Mar;
113:104624.
PMID: 32126256
An international expert working group representing 37 organisations (pharmaceutical/biotechnology companies, contract research organisations, academic institutions and regulatory bodies) collaborated in a data sharing exercise to evaluate the utility of two...
23.
Pugsley M, de Korte T, Udupa V, Authier S, Curtis M
J Pharmacol Toxicol Methods
. 2019 Jun;
99:106604.
PMID: 31254621
This editorial previews and summarizes the content of the current themed issue of J Pharm Tox Methods derived from the recent 2018 Annual Safety Pharmacology Society (SPS) meeting held in...
24.
Bass A, Pugsley M, Sannajust F, Yoshinaga T, Valentin J
J Pharmacol Toxicol Methods
. 2019 Jun;
98:106593.
PMID: 31158459
This commentary highlights and expands upon the thoughts conveyed in the lecture by Dr. Alan S. Bass, recipient of the 2017 Distinguished Service Award from the Safety Pharmacology Society, given...
25.
Pereira P, Pugsley M, Troncy E, Tan W, Pouliot M, Harper C, et al.
J Pharmacol Toxicol Methods
. 2019 Jun;
99:106589.
PMID: 31154034
Spontaneous arrhythmia characterization in healthy rats can support interpretation when studying novel therapies. Male (n = 55) and female (n = 40) Sprague-Dawley rats with telemetry transmitters for a derivation...
26.
Guth B, Grobler A, Frazier K, Greiter-Wilke A, Herzyk D, Hough T, et al.
J Pharmacol Toxicol Methods
. 2019 May;
98:106579.
PMID: 31085319
This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20-22, 2018 at the North-West University campus. There were...
27.
Pugsley M, Yong S, Goldin A, Hayes E, Walker M
Eur J Pharmacol
. 2018 Dec;
844:241-252.
PMID: 30571955
A series of amino-2-cyclohexyl ester derivatives were studied for their ion channel blocking and antiarrhythmic actions in the rat and a structure-activity analysis was conducted. The compounds are similar in...
28.
Boulay E, Abernathy M, Chui R, Friedrichs G, Gendron-Parra N, Greiter-Wilke A, et al.
Int J Toxicol
. 2018 Dec;
38(1):23-32.
PMID: 30567462
Introduction: Based on the ICH S7B and E14 guidance documents, QT interval (QTc) is used as the primary in vivo biomarker to assess the risk of drug-induced torsades de pointes...
29.
Pugsley M, Harter M, de Korte T, Connaughton C, Authier S, Curtis M
J Pharmacol Toxicol Methods
. 2018 Jun;
93:1-6.
PMID: 29936032
No abstract available.
30.
Chiang A, Guth B, Pugsley M, Foley C, Doyle J, Engwall M, et al.
J Pharmacol Toxicol Methods
. 2018 Mar;
92:43-51.
PMID: 29505899
Introduction: The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and...