John E Koerner
Overview
Explore the profile of John E Koerner including associated specialties, affiliations and a list of published articles.
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8
Citations
29
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0
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Recent Articles
1.
Chaudhary K, Clancy C, Yang P, Pierson J, Goldin A, Koerner J, et al.
Clin Transl Sci
. 2024 Dec;
17(12):e70098.
PMID: 39660576
The human voltage-gated sodium channel Na1.5 (hNa1.5/SCN5A) plays a critical role in the initiation and propagation of action potentials in cardiac myocytes, and its modulation by various drugs has significant...
2.
Authier S, Abernathy M, Correll K, Chui R, Dalton J, Foley C, et al.
Int J Toxicol
. 2020 May;
39(4):274-293.
PMID: 32406289
Introduction: The Safety Pharmacology Society (SPS) conducted a membership survey to examine industry practices related mainly to cardiovascular (CV) safety pharmacology (SP). Methods: Questions addressed nonclinical study design, data analysis...
3.
Boulay E, Abernathy M, Chui R, Friedrichs G, Gendron-Parra N, Greiter-Wilke A, et al.
Int J Toxicol
. 2018 Dec;
38(1):23-32.
PMID: 30567462
Introduction: Based on the ICH S7B and E14 guidance documents, QT interval (QTc) is used as the primary in vivo biomarker to assess the risk of drug-induced torsades de pointes...
4.
Chiang A, Guth B, Pugsley M, Foley C, Doyle J, Engwall M, et al.
J Pharmacol Toxicol Methods
. 2018 Mar;
92:43-51.
PMID: 29505899
Introduction: The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and...
5.
Authier S, Pugsley M, Koerner J, Fermini B, Redfern W, Valentin J, et al.
J Pharmacol Toxicol Methods
. 2017 Feb;
86:34-43.
PMID: 28223123
Introduction: The Safety Pharmacology Society (SPS) has conducted a survey of its membership to identify industry practices related to testing considered in the Comprehensive In vitro Proarrhythmia Assay (CiPA). Methods:...
6.
Pugsley M, Guth B, Chiang A, Doyle J, Engwall M, Guillon J, et al.
J Pharmacol Toxicol Methods
. 2017 Jan;
85:1-21.
PMID: 28065821
Introduction: The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety...
7.
Authier S, Curtis M, Soloviev M, Redfern W, Kallman M, Hamlin R, et al.
J Pharmacol Toxicol Methods
. 2015 May;
75:1-4.
PMID: 25959882
As with other professional disciplines there is a growing need from within industry as well as global regulatory authorities for implementation of a certification process in order to assure that...
8.
Zhang J, Herman E, Knapton A, Chadwick D, Whitehurst V, Koerner J, et al.
Toxicol Pathol
. 2002 Mar;
30(1):28-40.
PMID: 11890473
The characteristics and pathogenesis of the cardiovascular toxicity induced by the type III selective phosphodiesterase inhibitor SK&F 95654 were examined in 2 studies. Sprague-Dawley rats received either a single sc...