Michael K Pugsley
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Explore the profile of Michael K Pugsley including associated specialties, affiliations and a list of published articles.
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Citations
554
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Recent Articles
11.
Boulay E, Miraucourt L, Pugsley M, Abernathy M, Chui R, Dalton J, et al.
J Pharmacol Toxicol Methods
. 2023 Mar;
121:107266.
PMID: 36963703
Introduction: Characterization of the incidence of spontaneous arrhythmias to identify possible drug-related effects is often an important part of the analysis in safety pharmacology studies using telemetry. Methods: A retrospective...
12.
Pugsley M, Koshman Y, de Korte T, Authier S, Winters B, Curtis M
J Pharmacol Toxicol Methods
. 2022 Aug;
117:107206.
PMID: 35926772
The 2021 Annual Safety Pharmacology (SP) Society (SPS) meeting was held virtually October 4-8, 2021 due to the continuing COVID-19 global pandemic. This themed issue of J Pharmacol Toxicol Methods...
13.
Valentin J, Hoffmann P, Ortemann-Renon C, Koerner J, Pierson J, Gintant G, et al.
Toxicol Sci
. 2022 Feb;
187(1):3-24.
PMID: 35148401
The content of this article derives from a Health and Environmental Sciences Institute (HESI) consortium with a focus to improve cardiac safety during drug development. A detailed literature review was...
14.
Authier S, Brock W, Halpern W, Harris S, Jones D, Mcgovern T, et al.
Int J Toxicol
. 2021 Sep;
40(6):487-505.
PMID: 34569357
The growth in drug development over the past years reflects significant advancements in basic sciences and a greater understanding of molecular pathways of disease. Benchmarking industry practices has been important...
15.
Pugsley M, Koshman Y, de Korte T, Authier S, Curtis M
J Pharmacol Toxicol Methods
. 2021 Jun;
111:107089.
PMID: 34182120
This editorial summarizes the content of the current themed issue of J Pharmacol Toxicol Methods derived from the 2020 Annual Safety Pharmacology Society (SPS) meeting that was held virtually September...
16.
Devsi A, Kiyota B, Ouellette T, Hegle A, Rivera-Acevedo R, Wong J, et al.
J Cannabis Res
. 2021 Feb;
2(1):17.
PMID: 33526117
Background: Cannabis contains Δ-tetrahydrocannabinol (Δ-THC) and cannabidiol (CBD) as the primary constituents responsible for pharmacological activity. However, there are numerous additional chemically-related structures to Δ-THC and CBD that are pharmacologically...
17.
Pugsley M, Brooks M, Fishman C, Katavolos P, Chiang A, Parish S, et al.
J Pharmacol Toxicol Methods
. 2020 Oct;
107:106933.
PMID: 33122074
Introduction: Zucker diabetic fatty (ZDF) rats are used widely as an animal model of metabolic syndrome and insulin resistance. Our study focused on the effects of high versus low dietary...
18.
Boulay E, Troncy E, Accardi M, Pugsley M, Downey A, Miraucourt L, et al.
Int J Toxicol
. 2020 Oct;
39(6):530-541.
PMID: 33063577
Introduction: Corrected QT (QTc) interval is an essential proarrhythmic risk biomarker, but recent data have identified limitations to its use. The J to T-peak (JTp) interval is an alternative biomarker...
19.
Pugsley M, Bekele B, Griessel H, de Korte T, Authier S, Grobler A, et al.
J Pharmacol Toxicol Methods
. 2020 Aug;
105:106912.
PMID: 32798702
This editorial summarizes the content of the current themed issue of J Pharm Tox Methods derived from the 2019 Annual Safety Pharmacology Society (SPS) meeting held in Barcelona, Spain, and...
20.
Miraucourt L, Accardi M, Asin K, Pugsley M, Curtis M, Authier S
J Pharmacol Toxicol Methods
. 2020 May;
105:106883.
PMID: 32461084
Introduction: Pre-clinically, safety risk assessment of a drug is primarily tested in vivo using functional evaluation of adult animals while the mechanistic etiology of drug-induced CNS adverse effects is often...