Michael K Pugsley
Overview
Explore the profile of Michael K Pugsley including associated specialties, affiliations and a list of published articles.
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82
Citations
554
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Recent Articles
31.
Pugsley M, Authier S, Brabham T, Soloviev M, Markgraf C, Correll K, et al.
J Pharmacol Toxicol Methods
. 2017 Aug;
88(Pt 1):85-91.
PMID: 28797763
Introduction: Safety pharmacology is a growing discipline with scientists broadly distributed across international geographical regions. This electronic salary survey is the first to be distributed amongst the entire Safety Pharmacology...
32.
Pugsley M, de Korte T, Authier S, Huang H, Accardi M, Curtis M
J Pharmacol Toxicol Methods
. 2017 May;
87:1-6.
PMID: 28461240
This editorial prefaces the annual themed issue on safety pharmacology (SP) methods published in the Journal of Pharmacological and Toxicological Methods (JPTM). We highlight here the content derived from the...
33.
Boulay E, Pugsley M, Jacquemet V, Vinet A, Accardi M, Soloviev M, et al.
J Pharmacol Toxicol Methods
. 2017 Apr;
87:38-47.
PMID: 28434968
Introduction: QT has a long history of heart rate (HR) correction but limited investigations have been undertaken to assess the impact of cardiovascular parameters on left ventricular (LV) contractility in...
34.
Huang H, Pugsley M, Fermini B, Curtis M, Koerner J, Accardi M, et al.
J Pharmacol Toxicol Methods
. 2017 Apr;
87:11-23.
PMID: 28408211
Voltage gated ion channels are central in defining the fundamental properties of the ventricular cardiac action potential (AP), and are also involved in the development of drug-induced arrhythmias. Many drugs...
35.
Authier S, Pugsley M, Koerner J, Fermini B, Redfern W, Valentin J, et al.
J Pharmacol Toxicol Methods
. 2017 Feb;
86:34-43.
PMID: 28223123
Introduction: The Safety Pharmacology Society (SPS) has conducted a survey of its membership to identify industry practices related to testing considered in the Comprehensive In vitro Proarrhythmia Assay (CiPA). Methods:...
36.
Guth B, Pugsley M
J Pharmacol Toxicol Methods
. 2017 Feb;
87:24-26.
PMID: 28192184
No abstract available.
37.
Pugsley M, Guth B, Chiang A, Doyle J, Engwall M, Guillon J, et al.
J Pharmacol Toxicol Methods
. 2017 Jan;
85:1-21.
PMID: 28065821
Introduction: The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety...
38.
Pannirselvam M, Brabham T, Botchway A, Hodges D, Traebert M, Pugsley M
J Pharmacol Toxicol Methods
. 2016 Dec;
85:82-86.
PMID: 27913272
The Safety Pharmacology Society (SPS) held a Northeast (NE) regional meeting in Boston, MA on May 13, 2016 at the Vertex Pharmaceuticals Incorporated site. There were 103 attendees from the...
39.
Pugsley M, Authier S, Hayes E, Hamlin R, Accardi M, Curtis M
J Pharmacol Toxicol Methods
. 2016 Jun;
81:1-8.
PMID: 27343819
Safety pharmacology (SP) has evolved in terms of architecture and content since the inception of the SP Society (SPS). SP was initially focused on the issue of drug-induced QT prolongation,...
40.
Authier S, Arezzo J, Delatte M, Kallman M, Markgraf C, Paquette D, et al.
J Pharmacol Toxicol Methods
. 2016 Jun;
81:37-46.
PMID: 27263834
The Safety Pharmacology Society (SPS) conducted an industry survey in 2015 to identify industry practices as they relate to central, peripheral and autonomic nervous system ('CNS') drug safety testing. One...