Michael J Rynkiewicz
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Explore the profile of Michael J Rynkiewicz including associated specialties, affiliations and a list of published articles.
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52
Citations
704
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Recent Articles
1.
Barry M, Rynkiewicz M, Wen J, Tu A, Regnier M, Lehman W, et al.
Arch Biochem Biophys
. 2025 Mar;
768:110380.
PMID: 40057222
β-adrenergic stimulation causes cell signaling that targets modulation of calcium levels as well as sarcomeric proteins to increases contractility. PKA phosphorylation of serine residues 23 and 24 of troponin I...
2.
Doran M, Rynkiewicz M, Despond E, Viswanathan M, Madan A, Chitre K, et al.
iScience
. 2025 Feb;
28(2):111816.
PMID: 39981516
Previous studies aimed at defining the mechanistic basis of hypertrophic cardiomyopathy caused by A331P cardiac actin have reported conflicting results. The mutation is located along an actin surface strand, proximal...
3.
Campbell S, Moore J, Rynkiewicz M, Lehman W
J Mol Cell Cardiol Plus
. 2025 Jan;
3():100025.
PMID: 39803360
No abstract available.
4.
Halder S, Rynkiewicz M, Kim L, Barry M, Zied A, Sewanan L, et al.
J Clin Invest
. 2024 Oct;
134(24).
PMID: 39436707
Heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) represent starkly diverging clinical phenotypes, yet may be caused by mutations to the same sarcomeric protein. The precise mechanisms by...
5.
Creso J, Gokhan I, Rynkiewicz M, Lehman W, Moore J, Campbell S
Front Physiol
. 2024 Sep;
15:1452509.
PMID: 39282088
Dilated cardiomyopathy (DCM) is an inherited disorder often leading to severe heart failure. Linkage studies in affected families have revealed hundreds of different mutations that can cause DCM, with most...
6.
Rynkiewicz M, Childers M, Karpicheva O, Regnier M, Geeves M, Lehman W
J Gen Physiol
. 2024 Apr;
156(5).
PMID: 38607351
Dynamic interactions between the myosin motor head on thick filaments and the actin molecular track on thin filaments drive the myosin-crossbridge cycle that powers muscle contraction. The process is initiated...
7.
Barry M, Rynkiewicz M, Pavadai E, Viana A, Lehman W, Moore J
J Mol Cell Cardiol
. 2024 Jan;
188:30-37.
PMID: 38266978
The cardiac thin filament proteins troponin and tropomyosin control actomyosin formation and thus cardiac contractility. Calcium binding to troponin changes tropomyosin position along the thin filament, allowing myosin head binding...
8.
Lewkowicz E, Nakamura M, Rynkiewicz M, Gursky O
Cell Mol Life Sci
. 2023 Nov;
80(12):376.
PMID: 38010414
Apolipoproteins co-deposit with amyloids, yet apolipoprotein-amyloid interactions are enigmatic. To understand how apoE interacts with Alzheimer's amyloid-β (Aβ) peptide in fibrillary deposits, the NMR structure of full-length human apoE was...
9.
Lewkowicz E, Nakamura M, Rynkiewicz M, Gursky O
bioRxiv
. 2023 Aug;
PMID: 37577501
Apolipoproteins co-deposit with amyloids, yet apolipoprotein-amyloid interactions are enigmatic. To understand how apoE interacts with Alzheimer's amyloid-β (Aβ) peptide in fibrillary deposits, the NMR structure of full-length human apoE was...
10.
Lehman W, Rynkiewicz M
J Gen Physiol
. 2023 May;
155(7).
PMID: 37249525
Regulation of the crossbridge cycle that drives muscle contraction involves a reconfiguration of the troponin-tropomyosin complex on actin filaments. By comparing atomic models of troponin-tropomyosin fitted to cryo-EM structures of...