Toby S Scott-Ward
Overview
Explore the profile of Toby S Scott-Ward including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
124
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Recent Articles
1.
Bose S, Scott-Ward T, Cai Z, Sheppard D
Biochem Soc Trans
. 2015 Oct;
43(5):975-82.
PMID: 26517912
The anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding cassette (ABC) transporter. CFTR plays a pivotal role in transepithelial ion transport as its dysfunction in the...
2.
Cai Z, Palmai-Pallag T, Khuituan P, Mutolo M, Boinot C, Liu B, et al.
J Physiol
. 2015 Mar;
593(11):2427-46.
PMID: 25763566
Key Points: Malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a gated pathway for chloride movement, causes the common life-shortening genetic disease cystic fibrosis (CF). Towards the development of...
3.
Ju M, Scott-Ward T, Liu J, Khuituan P, Li H, Cai Z, et al.
Br J Pharmacol
. 2013 Oct;
171(1):265-78.
PMID: 24117047
Background And Purpose: Loop diuretics are widely used to inhibit the Na(+), K(+), 2Cl(-) co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. Here, we...
4.
Contreras-Sanz A, Scott-Ward T, Gill H, Jacoby J, Birch R, Malone-Lee J, et al.
Purinergic Signal
. 2012 Jun;
8(4):741-51.
PMID: 22707011
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through...
5.
Scott-Ward T, Amaral M
FEBS J
. 2009 Nov;
276(23):7097-109.
PMID: 19878303
The primary cause of cystic fibrosis (CF), the most frequent fatal genetic disease in Caucasians, is deletion of phenylalanine at position 508 (F508del), located in the first nucleotide-binding domain (NBD1)...
6.
Scott-Ward T, Cai Z, Dawson E, Doherty A, Da Paula A, Davidson H, et al.
Proc Natl Acad Sci U S A
. 2007 Oct;
104(41):16365-70.
PMID: 17913891
The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(-) channel gated by ATP-driven nucleotide-binding domain (NBD) dimerization. Here we exploit species differences between human and murine CFTR to investigate...
7.
Cai Z, Scott-Ward T, Li H, Schmidt A, Sheppard D
J Cyst Fibros
. 2004 Oct;
3 Suppl 2:141-7.
PMID: 15463947
The malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is associated with a wide spectrum of disease. In the search for modulators of CFTR, pharmaceutical agents have...
8.
Sheppard D, Gray M, Gong X, Sohma Y, Kogan I, Benos D, et al.
J Cyst Fibros
. 2004 Oct;
3 Suppl 2:101-8.
PMID: 15463939
Using the patch-clamp (PC) and planar lipid bilayer (PLB) techniques the molecular behaviour of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel can be visualised in real-time. The PC...
9.
Cai Z, Scott-Ward T, Sheppard D
J Gen Physiol
. 2003 Oct;
122(5):605-20.
PMID: 14581585
When excised inside-out membrane patches are bathed in symmetrical Cl--rich solutions, the current-voltage (I-V) relationship of macroscopic cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents inwardly rectifies at large positive...