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Michael J Kraakman

Explore the profile of Michael J Kraakman including associated specialties, affiliations and a list of published articles. Areas
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Articles 33
Citations 925
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Recent Articles
1.
Ransmayr B, Bal S, Thian M, Svaton M, van de Wetering C, Hafemeister C, et al.
Sci Immunol . 2024 Nov; 9(101):eadq8796. PMID: 39576873
Secondary lymphoid organs (SLOs) provide the confined microenvironment required for stromal cells to interact with immune cells to initiate adaptive immune responses resulting in B cell differentiation. Here, we studied...
2.
Karakus I, Catak M, Frohne A, Bayram Catak F, Yorgun Altunbas M, Babayeva R, et al.
J Clin Immunol . 2024 Apr; 44(4):94. PMID: 38578569
Purpose: Deficiency of stromal interaction molecule 1 (STIM1) results in combined immunodeficiency accompanied by extra-immunological findings like enamel defects and myopathy. We here studied a patient with a STIM1 loss-of-function...
3.
Bal S, Giuliani S, Block J, Repiscak P, Hafemeister C, Shahin T, et al.
Blood . 2023 May; 142(9):827-845. PMID: 37249233
The nuclear factor of activated T cells (NFAT) family of transcription factors plays central roles in adaptive immunity in murine models; however, their contribution to human immune homeostasis remains poorly...
4.
Dragoljevic D, Lee M, Pernes G, Morgan P, Louis C, Shihata W, et al.
Clin Transl Immunology . 2023 Apr; 12(4):e1446. PMID: 37091327
Objectives: The leading cause of mortality in patients with rheumatoid arthritis is atherosclerotic cardiovascular disease (CVD). We have shown that murine arthritis impairs atherosclerotic lesion regression, because of cellular cholesterol...
5.
Izquierdo M, Shanmugarajah N, Lee S, Kraakman M, Westerterp M, Kitamoto T, et al.
J Clin Invest . 2022 Feb; 132(7). PMID: 35104242
Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular...
6.
Dragoljevic D, Veiga C, Michell D, Shihata W, Al-Sharea A, Head G, et al.
Biomed Pharmacother . 2021 Jul; 139:111668. PMID: 34243630
Metabolic Syndrome (MetS) is a complex and multifactorial condition often characterised by obesity, hypertension, hyperlipidaemia, insulin resistance, glucose intolerance and fasting hyperglycaemia. Collectively, MetS can increase the risk of atherosclerotic-cardiovascular...
7.
Aaron N, Kraakman M, Zhou Q, Liu Q, Costa S, Yang J, et al.
Elife . 2021 Jun; 10. PMID: 34155972
Background: Marrow adipose tissue (MAT) has been shown to be vital for regulating metabolism and maintaining skeletal homeostasis in the bone marrow (BM) niche. As a reflection of BM remodeling,...
8.
Kalinichenko A, Perinetti Casoni G, Dupre L, Trotta L, Huemer J, Galgano D, et al.
Blood . 2021 Jan; 137(15):2033-2045. PMID: 33513601
Exocytosis of cytotoxic granules (CG) by lymphocytes is required for the elimination of infected and malignant cells. Impairments in this process underly a group of diseases with dramatic hyperferritinemic inflammation...
9.
Lee M, Kraakman M, Dragoljevic D, Hanssen N, Flynn M, Al-Sharea A, et al.
Arterioscler Thromb Vasc Biol . 2021 Jan; 41(3):1167-1178. PMID: 33441028
Objective: People with diabetes are at a significantly higher risk of cardiovascular disease, in part, due to accelerated atherosclerosis. Diabetic subjects have increased number of platelets that are activated, more...
10.
Dragoljevic D, Lee M, Louis C, Shihata W, Kraakman M, Hansen J, et al.
Clin Transl Immunology . 2020 Nov; 9(11):e1206. PMID: 33204425
Objectives: Rheumatoid arthritis (RA), an inflammatory joint disorder, independently increases the risk of cardiovascular disease (CVD). IL-1β contributes to both RA and CVD. We hypothesised that inhibiting IL-1 signalling with...