Michelle C Flynn
Overview
Explore the profile of Michelle C Flynn including associated specialties, affiliations and a list of published articles.
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13
Citations
337
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Recent Articles
1.
Forbes J, McCarthy D, Kassianos A, Baskerville T, Fotheringham A, Giuliani K, et al.
Diabetes
. 2021 Jul;
70(8):1754-1766.
PMID: 34285121
Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes,...
2.
Cohen C, De Blasio M, Lee M, Farrugia G, Prakoso D, Krstevski C, et al.
Cardiovasc Diabetol
. 2021 Jun;
20(1):116.
PMID: 34074290
Background: Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with cellular changes...
3.
Lee M, Kraakman M, Dragoljevic D, Hanssen N, Flynn M, Al-Sharea A, et al.
Arterioscler Thromb Vasc Biol
. 2021 Jan;
41(3):1167-1178.
PMID: 33441028
Objective: People with diabetes are at a significantly higher risk of cardiovascular disease, in part, due to accelerated atherosclerosis. Diabetic subjects have increased number of platelets that are activated, more...
4.
Hanssen N, Kraakman M, Flynn M, Nagareddy P, Schalkwijk C, Murphy A
Front Cardiovasc Med
. 2020 Nov;
7:570553.
PMID: 33195459
Clinical trials investigating whether glucose lowering treatment reduces the risk of CVD in diabetes have thus far yielded mixed results. However, this doesn't rule out the possibility of hyperglycemia playing...
5.
Sreejit G, Flynn M, Patil M, Krishnamurthy P, Murphy A, Nagareddy P
Adv Clin Chem
. 2020 Jun;
98:173-231.
PMID: 32564786
The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy...
6.
Flynn M, Kraakman M, Tikellis C, Lee M, Hanssen N, Kammoun H, et al.
Circ Res
. 2020 Jun;
127(7):877-892.
PMID: 32564710
Rationale: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend...
7.
Pernes G, Flynn M, Lancaster G, Murphy A
Clin Transl Immunology
. 2020 Jan;
8(12):e1098.
PMID: 31890207
The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution...
8.
Lee M, Al-Sharea A, Shihata W, Veiga C, Cooney O, Fleetwood A, et al.
Front Immunol
. 2019 Sep;
10:2054.
PMID: 31555280
Monocytes in humans consist of 3 subsets; CD14CD16 (classical), CD14CD16 (intermediate) and CD14CD16 (non-classical), which exhibit distinct and heterogeneous responses to activation. During acute inflammation CD14CD16 monocytes are significantly elevated...
9.
Flynn M, Pernes G, Lee M, Nagareddy P, Murphy A
Front Pharmacol
. 2019 Jun;
10:666.
PMID: 31249530
Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease, in which macrophages are responsible for taking up these lipids and driving disease progression. Over the years, we and others...
10.
Dragoljevic D, Kraakman M, Nagareddy P, Ngo D, Shihata W, Kammoun H, et al.
Eur Heart J
. 2018 Jun;
39(23):2158-2167.
PMID: 29905812
Aim: Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail...