Michael J Hendzel
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Explore the profile of Michael J Hendzel including associated specialties, affiliations and a list of published articles.
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102
Citations
5529
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Recent Articles
1.
Knechtel J, Strickfaden H, Missiaen K, Hadfield J, Hendzel M, Underhill D
EMBO Rep
. 2024 Nov;
26(1):153-174.
PMID: 39562713
A defining feature of constitutive heterochromatin compartments is the heterochromatin protein-1 (HP1) family, whose members display fast internal mobility and rapid exchange with the surrounding nucleoplasm. Here, we describe a...
2.
Kalani L, Kim B, de Chavez A, Roemer A, Mikhailov A, Merritt J, et al.
Hum Mol Genet
. 2024 Aug;
33(21):1833-1845.
PMID: 39137370
Mutations in methyl-CpG binding protein 2 (MeCP2), such as the T158M, P152R, R294X, and R306C mutations, are responsible for most Rett syndrome (RTT) cases. These mutations often result in altered...
3.
Ngubo M, Chen Z, McDonald D, Karimpour R, Shrestha A, Yockell-Lelievre J, et al.
Aging Cell
. 2024 Apr;
23(7):e14150.
PMID: 38576084
Hutchinson-Gilford Progeria syndrome (HGPS) is a lethal premature aging disorder caused by a de novo heterozygous mutation that leads to the accumulation of a splicing isoform of Lamin A termed...
4.
Otsuka A, Minami K, Higashi K, Kawaguchi A, Tamura S, Ide S, et al.
Chromosoma
. 2024 Feb;
133(2):135-148.
PMID: 38400910
In higher eukaryotic cells, a string of nucleosomes, where long genomic DNA is wrapped around core histones, are rather irregularly folded into a number of condensed chromatin domains, which have...
5.
OSullivan J, Kothari C, Caron M, Gagne J, Jin Z, Nonfoux L, et al.
Nucleic Acids Res
. 2023 Oct;
51(20):11056-11079.
PMID: 37823600
Zinc finger (ZNF) motifs are some of the most frequently occurring domains in the human genome. It was only recently that ZNF proteins emerged as key regulators of genome integrity...
6.
Beneyton A, Nonfoux L, Gagne J, Rodrigue A, Kothari C, Atalay N, et al.
NAR Cancer
. 2023 Aug;
5(3):zcad043.
PMID: 37609662
Poly(ADP-ribosylation) (PARylation) by poly(ADP-ribose) polymerases (PARPs) is a highly regulated process that consists of the covalent addition of polymers of ADP-ribose (PAR) through post-translational modifications of substrate proteins or non-covalent...
7.
Gelleri M, Chen S, Hubner B, Neumann J, Kroger O, Sadlo F, et al.
Cell Rep
. 2023 May;
42(6):112567.
PMID: 37243597
Chromatin compaction differences may have a strong impact on accessibility of individual macromolecules and macromolecular assemblies to their DNA target sites. Estimates based on fluorescence microscopy with conventional resolution, however,...
8.
Strickfaden H, Abate N, Forster C, Wuest F, Underhill D, Hendzel M
Microscopy (Oxf)
. 2023 Apr;
72(4):299-309.
PMID: 37040437
Transmission electron microscopy (TEM) has been essential in defining the structural organization of the cell due to its ability to image cell structures at molecular resolution. However, the absence of...
9.
Roemer A, Mohammed L, Strickfaden H, Underhill D, Hendzel M
Front Genet
. 2022 Sep;
13:876862.
PMID: 36092926
Chromatin is thought to regulate the accessibility of the underlying DNA sequence to machinery that transcribes and repairs the DNA. Heterochromatin is chromatin that maintains a sufficiently high density of...
10.
Abate N, Hendzel M
Front Genet
. 2022 Aug;
13:887088.
PMID: 35923694
Cells assemble compartments around DNA double-strand breaks (DSBs). The assembly of this compartment is dependent on the phosphorylation of histone H2AX, the binding of MDC1 to phosphorylated H2AX, and the...