Ismail Hassan Ismail
Overview
Explore the profile of Ismail Hassan Ismail including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
26
Citations
905
Followers
0
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Recent Articles
1.
Mashayekhi F, Ganje C, Caron M, Heyza J, Gao Y, Zeinali E, et al.
Cell Rep
. 2024 Dec;
43(12):115066.
PMID: 39671289
Uncontrolled degradation and collapse of stalled replication forks (RFs) are primary sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse remain to be fully elaborated. Here,...
2.
Mashayekhi F, Zeinali E, Ganje C, Fanta M, Li L, Godbout R, et al.
J Biol Chem
. 2024 Oct;
300(11):107880.
PMID: 39395804
Okazaki fragment maturation (OFM) stands as a pivotal DNA metabolic process, crucial for genome integrity and cell viability. Dysregulation of OFM leads to DNA single-strand breaks-accumulation, which is linked to...
3.
Mashhouri S, Rahmati A, Azimi A, Fava R, Ismail I, Walker J, et al.
Cell Oncol (Dordr)
. 2024 Apr;
47(5):1735-1756.
PMID: 38668817
Purpose: Acquired resistance to immune checkpoint blockers (ICBs) is a major barrier in cancer treatment, emphasizing the need for innovative strategies. Dectin-1 (gene Clec7a) is a C-type lectin receptor best...
4.
Locke A, Abou Farraj R, Tran C, Zeinali E, Mashayekhi F, Ali J, et al.
J Biol Chem
. 2024 Feb;
300(3):105709.
PMID: 38309501
Double-strand breaks (DSBs) are DNA lesions that pose a significant threat to genomic stability. The repair of DSBs by the homologous recombination (HR) pathway is preceded by DNA end resection,...
5.
Lovsund T, Mashayekhi F, Fitieh A, Stafford J, Ismail I
Cells
. 2023 Jul;
12(14).
PMID: 37508568
Detailing the connection between homeostatic functions of enzymatic families and eventual progression into tumorigenesis is crucial to our understanding of anti-cancer therapies. One key enzyme group involved in this process...
6.
Sharma A, Fitieh A, Ali J, Ismail I
STAR Protoc
. 2023 Jan;
3(4):101861.
PMID: 36595899
DNA end resection is a critical step in the homologous recombination pathway of repairing DNA double-strand breaks (DSBs) that can be visualized in cells by detecting the generation of single-stranded...
7.
Sharma A, Fitieh A, Locke A, Ali J, Ismail I
STAR Protoc
. 2022 Dec;
4(1):101917.
PMID: 36520630
Here, we present a chromatin-immunoprecipitation-based protocol to quantify the recruitment of proteins adjacent to site-specific DNA double-strand breaks (DSBs), such as proteins involved in DSB repair. We describe steps to...
8.
Ali J, Fitieh A, Ismail I
Int J Mol Sci
. 2022 May;
23(10).
PMID: 35628498
Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently,...
9.
Rashed F, Diaz-Dussan D, Mashayekhi F, Macdonald D, Nation P, Yang X, et al.
Redox Biol
. 2022 Apr;
52:102300.
PMID: 35430547
Solid tumours are often poorly oxygenated, which confers resistance to standard treatment modalities. Targeting hypoxic tumours requires compounds, such as nitroimidazoles (NIs), equipped with the ability to reach and become...
10.
Fitieh A, Locke A, Mashayekhi F, Khaliqdina F, Sharma A, Ismail I
Cell Rep
. 2022 Mar;
38(12):110536.
PMID: 35320715
BMI-1 is an essential regulator of transcriptional silencing during development. Recently, the role of BMI-1 in the DNA damage response has gained much attention, but the exact mechanism of how...