Michael J Hendzel
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Explore the profile of Michael J Hendzel including associated specialties, affiliations and a list of published articles.
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102
Citations
5529
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Recent Articles
11.
Hansen J, Maeshima K, Hendzel M
Epigenetics Chromatin
. 2021 Oct;
14(1):50.
PMID: 34717733
The review begins with a concise description of the principles of phase separation. This is followed by a comprehensive section on phase separation of chromatin, in which we recount the...
12.
Ali M, Garcia-Vilas J, Cromwell C, Hubbard B, Hendzel M, Schulz R
FEBS J
. 2021 Jun;
288(23):6736-6751.
PMID: 34101354
Cell proliferation and survival require continuous ribosome biogenesis and protein synthesis. Genes encoding ribosomal RNA are physically located in a specialized substructure within the nucleus known as the nucleolus, which...
13.
14.
Strickfaden H, Tolsma T, Sharma A, Underhill D, Hansen J, Hendzel M
Cell
. 2020 Dec;
183(7):1772-1784.e13.
PMID: 33326747
The association of nuclear DNA with histones to form chromatin is essential for temporal and spatial control of eukaryotic genomes. In this study, we examined the physical state of condensed...
15.
Caron M, Sharma A, OSullivan J, Myler L, Ferreira M, Rodrigue A, et al.
Nat Commun
. 2019 Jul;
10(1):2954.
PMID: 31273204
PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the...
16.
OSullivan J, Ferreira M, Gagne J, Sharma A, Hendzel M, Masson J, et al.
Nat Commun
. 2019 Mar;
10(1):1182.
PMID: 30862789
Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It is modulated through a dynamic interplay between ADP-ribose readers, writers and...
17.
Mani R, Mermershtain I, Abdou I, Fanta M, Hendzel M, Glover J, et al.
J Biol Chem
. 2018 Nov;
294(2):520-530.
PMID: 30446622
Polynucleotide kinase/phosphatase (PNKP) and X-ray repair cross-complementing 1 (XRCC1) are key proteins in the single-strand DNA break repair pathway. Phosphorylated XRCC1 stimulates PNKP by binding to its forkhead-associated (FHA) domain,...
18.
Sharma A, Hendzel M
Int J Radiat Biol
. 2018 Sep;
95(4):382-393.
PMID: 30252564
Purpose: The cellular response to DNA damage occurs in the context of an organized chromatin environment in order to maintain genome integrity. Immediately after DNA damage, an array of histone...
19.
Contreras C, Villasana M, Hendzel M, Carrero G
PLoS One
. 2018 Jan;
13(1):e0191562.
PMID: 29352283
Histones H1 or linker histones are highly dynamic proteins that diffuse throughout the cell nucleus and associate with chromatin (DNA and associated proteins). This binding interaction of histone H1 with...
20.
Ali M, Strickfaden H, Lee B, Spyracopoulos L, Hendzel M
Cell Rep
. 2018 Jan;
22(2):383-395.
PMID: 29320735
Ring1-YY1-binding protein (RYBP) is a member of the non-canonical polycomb repressive complex 1 (PRC1), and like other PRC1 members, it is best described as a transcriptional regulator. However, several PRC1...