Michael J Gerdes
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Explore the profile of Michael J Gerdes including associated specialties, affiliations and a list of published articles.
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19
Citations
974
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Recent Articles
1.
Hayes J, Abdul-Rahman N, Gerdes M, Musah R
Anal Chem
. 2021 Nov;
93(46):15306-15314.
PMID: 34761917
Coral reefs are one of the most biologically diverse ecosystems, and the accurate identification of the species is essential for diversity assessment and conservation. Current genus determination approaches are time-consuming...
2.
Yan Y, Leontovich A, Gerdes M, Desai K, Dong J, Sood A, et al.
PLoS One
. 2019 Jun;
14(6):e0216485.
PMID: 31166985
A systemic analysis of the tumor-immune interactions within the heterogeneous tumor microenvironment is of particular importance for understanding the antitumor immune response. We used multiplexed immunofluorescence to elucidate cellular spatial...
3.
Herring C, Banerjee A, McKinley E, Simmons A, Ping J, Roland J, et al.
Cell Syst
. 2017 Nov;
6(1):37-51.e9.
PMID: 29153838
Modern single-cell technologies allow multiplexed sampling of cellular states within a tissue. However, computational tools that can infer developmental cell-state transitions reproducibly from such single-cell data are lacking. Here, we...
4.
Gerdes M, Gokmen-Polar Y, Sui Y, Pang A, LaPlante N, Harris A, et al.
Mod Pathol
. 2017 Nov;
31(3):406-417.
PMID: 29148540
Heterogeneous patterns of mutations and RNA expression have been well documented in invasive cancers. However, technological challenges have limited the ability to study heterogeneity of protein expression. This is particularly...
5.
McKinley E, Sui Y, Al-Kofahi Y, Millis B, Tyska M, Roland J, et al.
JCI Insight
. 2017 Jun;
2(11).
PMID: 28570279
Intestinal tuft cells are a rare, poorly understood cell type recently shown to be a critical mediator of type 2 immune response to helminth infection. Here, we present advances in...
6.
Surrette C, Shoudy D, Corwin A, Gao W, Zavodszky M, Karsten S, et al.
SLAS Technol
. 2016 Nov;
22(4):425-430.
PMID: 27864340
We present a mesodissection platform that retains the advantages of laser-based dissection instrumentation with the speed and ease of manual dissection. Tissue dissection in clinical laboratories is often performed by...
7.
Simmons A, Banerjee A, McKinley E, Scurrah C, Herring C, Gewin L, et al.
Mol Syst Biol
. 2016 Aug;
12(8):881.
PMID: 27574014
No abstract available.
8.
Simmons A, Banerjee A, McKinley E, Scurrah C, Herring C, Gewin L, et al.
Mol Syst Biol
. 2015 Nov;
11(10):835.
PMID: 26519361
Understanding heterogeneous cellular behaviors in a complex tissue requires the evaluation of signaling networks at single-cell resolution. However, probing signaling in epithelial tissues using cytometry-based single-cell analysis has been confounded...
9.
Gerdes M, Sood A, Sevinsky C, Pris A, Zavodszky M, Ginty F
Front Oncol
. 2015 Jan;
4:366.
PMID: 25566504
Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer heterogeneity are summarized by 10 acquired...
10.
Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell A, et al.
J Clin Invest
. 2014 Apr;
124(5):2172-87.
PMID: 24691442
The epithelial-to-mesenchymal transition (EMT) transcriptional program is characterized by repression of E-cadherin (CDH1) and induction of N-cadherin (CDH2), and mesenchymal genes like vimentin (VIM). Placenta-specific 8 (PLAC8) has been implicated...