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Michael I Bukrinsky

Explore the profile of Michael I Bukrinsky including associated specialties, affiliations and a list of published articles. Areas
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Citations 631
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Recent Articles
1.
Schenck J, Clarkson-Paredes C, Pushkarsky T, Wang Y, Miller R, Bukrinsky M
Life Sci Alliance . 2024 Nov; 8(2). PMID: 39532531
The introduction of antiretroviral therapy has markedly improved the management of HIV-associated neurocognitive disorders (HAND). However, HAND still affects nearly half of HIV-infected individuals, presenting significant challenges to their well-being....
2.
Liu B, Rakhmanina N, Yang Z, Bukrinsky M
Viruses . 2024 May; 16(5). PMID: 38793665
Epidemiologic studies have established that mpox (formerly known as monkeypox) outbreaks worldwide in 2022-2023, due to Clade IIb mpox virus (MPXV), disproportionately affected gay, bisexual, and other men who have...
3.
Schenck J, Karl M, Clarkson-Paredes C, Bastin A, Pushkarsky T, Brichacek B, et al.
J Neuroinflammation . 2024 May; 21(1):127. PMID: 38741181
HIV-associated neurocognitive disorders (HAND) are a spectrum of cognitive impairments that continue to affect approximately half of all HIV-positive individuals despite effective viral suppression through antiretroviral therapy (ART). White matter...
4.
Dubrovsky L, Brichacek B, Prashant N, Pushkarsky T, Mukhamedova N, Fleetwood A, et al.
Cell Rep . 2022 Nov; 41(8):111674. PMID: 36417867
A possible explanation for chronic inflammation in HIV-infected individuals treated with anti-retroviral therapy is hyperreactivity of myeloid cells due to a phenomenon called "trained immunity." Here, we demonstrate that human...
5.
Sviridov D, Miller Y, Bukrinsky M
Front Immunol . 2022 Jul; 13:903884. PMID: 35874772
Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon...
6.
Pushkarsky T, Ward A, Ivanov A, Lin X, Sviridov D, Nekhai S, et al.
Mol Neurobiol . 2021 Nov; 59(2):1088-1097. PMID: 34843091
HIV-associated neurocognitive disorders (HAND) is a term used to describe a variety of neurological impairments observed in HIV-infected individuals. The pathogenic mechanisms of HAND and of its connection to HIV...
7.
Adzhubei A, Kulkarni A, Tolstova A, Anashkina A, Sviridov D, Makarov A, et al.
Comput Struct Biotechnol J . 2021 Sep; 19:3876-3884. PMID: 34584633
HIV-1 infection impairs cellular cholesterol efflux by downmodulating the cholesterol transporter ABCA1, leading to metabolic co-morbidities like cardio-vascular disease. The main mechanism of this effect is impairment by the HIV-1...
8.
Golubovskaya V, Bukrinsky M, Grizzi F
Vaccines (Basel) . 2020 Aug; 8(3). PMID: 32731435
The term "Exosomes" defines small extracellular vesicles, ranging from 30 to 150 nm in diameter, secreted by most eukaryotic cells into surrounding body fluids including blood, saliva, urine, bile and...
9.
Ballout R, Sviridov D, Bukrinsky M, Remaley A
FASEB J . 2020 May; 34(6):7253-7264. PMID: 32367579
Drug repurposing is potentially the fastest available option in the race to identify safe and efficacious drugs that can be used to prevent and/or treat COVID-19. By describing the life...
10.
Bukrinsky M, Mukhamedova N, Sviridov D
J Lipid Res . 2019 Oct; 61(5):601-610. PMID: 31615838
Lipid rafts, solid regions of the plasma membrane enriched in cholesterol and glycosphingolipids, are essential parts of a cell. Functionally, lipid rafts present a platform that facilitates interaction of cells...