Michael Hons
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Explore the profile of Michael Hons including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
184
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Recent Articles
1.
Kril V, Hons M, Amadori C, Zimberger C, Couture L, Bouery Y, et al.
Nat Commun
. 2024 Sep;
15(1):8106.
PMID: 39285216
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming. Efficient alphavirus infection relies on...
2.
Sharma R, Adams M, Griffith-Jones S, Sahr T, Gomez-Valero L, Weis F, et al.
Nat Commun
. 2023 Nov;
14(1):7068.
PMID: 37923743
Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to...
3.
Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
Lethier M, Huard K, Hons M, Favier A, Brutscher B, Boeri Erba E, et al.
Life Sci Alliance
. 2023 Sep;
6(11).
PMID: 37673444
RIPK2 is an essential adaptor for NOD signalling and its kinase domain is a drug target for NOD-related diseases, such as inflammatory bowel disease. However, recent work indicates that the...
4.
Khazma T, Grossman A, Guez-Haddad J, Feng C, Dabas H, Sain R, et al.
Cell Rep
. 2023 Aug;
42(9):113026.
PMID: 37635352
Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of SARM1, a protein that...
5.
Jones R, Hons M, Rabah N, Zamarreno N, Arranz R, Reguera J
Proc Natl Acad Sci U S A
. 2023 Mar;
120(12):e2213934120.
PMID: 36913573
Alphaviruses are emerging positive-stranded RNA viruses which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm. The nonstructural protein 1 (nsP1) is responsible for viral RNA...
6.
Khazma T, Golan-Vaishenker Y, Guez-Haddad J, Grossman A, Sain R, Weitman M, et al.
Cell Mol Life Sci
. 2023 Feb;
80(3):68.
PMID: 36814037
No abstract available.
7.
Khazma T, Golan-Vaishenker Y, Guez-Haddad J, Grossman A, Sain R, Weitman M, et al.
Cell Mol Life Sci
. 2022 Dec;
80(1):16.
PMID: 36564647
In recent years, there has been growing interest in SARM1 as a potential breakthrough drug target for treating various pathologies of axon degeneration. SARM1-mediated axon degeneration relies on its TIR...
8.
Leisico F, Omeiri J, Le Narvor C, Beaudouin J, Hons M, Fenel D, et al.
Nat Commun
. 2022 Nov;
13(1):7110.
PMID: 36402845
Heparan sulfates are complex polysaccharides that mediate the interaction with a broad range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is catalyzed by...
9.
Giachin G, Jessop M, Bouverot R, Acajjaoui S, Saidi M, Chretien A, et al.
Angew Chem Int Ed Engl
. 2020 Dec;
60(9):4689-4697.
PMID: 33320993
Fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are mitochondrial redox processes that generate ATP. The biogenesis of the respiratory Complex I, a 1 MDa multiprotein complex that is responsible...
10.
Sporny M, Guez-Haddad J, Khazma T, Yaron A, Dessau M, Shkolnisky Y, et al.
Elife
. 2020 Nov;
9.
PMID: 33185189
SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under...