Michael H B Stowell
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Explore the profile of Michael H B Stowell including associated specialties, affiliations and a list of published articles.
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38
Citations
733
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Recent Articles
11.
Park J, Li J, Mayer J, Ball K, Wu J, Hall C, et al.
Nat Commun
. 2022 Sep;
13(1):5594.
PMID: 36151101
Insulin receptor (IR) signaling defects cause a variety of metabolic diseases including diabetes. Moreover, inherited mutations of the IR cause severe insulin resistance, leading to early morbidity and mortality with...
12.
Basta T, Morgan G, OToole E, Rao N, Savas J, Stowell M
Methods Mol Biol
. 2022 Jul;
2473:129-139.
PMID: 35819763
Electron tomography of the chemical synapse provides important architectural information regarding the organization of synaptic organelles including synaptic vesicles, Nissl bodies, and early endosomes. Here, we describe methods for the...
13.
Guard S, Chapnick D, Poss Z, Ebmeier C, Jacobsen J, Nemkov T, et al.
Mol Cell Proteomics
. 2022 Jun;
21(10):100262.
PMID: 35753663
The nonpsychoactive cannabinoid, cannabidiol (CBD), is Food and Dug Administration approved for treatment of two drug-resistant epileptic disorders and is seeing increased use among the general public, yet the mechanisms...
14.
Li J, Park J, Mayer J, Webb K, Uchikawa E, Wu J, et al.
Nat Struct Mol Biol
. 2022 Apr;
29(4):357-368.
PMID: 35361965
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of...
15.
Rahman M, Basta T, Teng J, Lee M, Worrell B, Stowell M, et al.
Nat Struct Mol Biol
. 2022 Mar;
29(4):386-394.
PMID: 35301478
Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to understand at the level of three-dimensional structure how...
16.
Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, et al.
Cell
. 2022 Mar;
185(8):1346-1355.e15.
PMID: 35247328
Misfolding and aggregation of disease-specific proteins, resulting in the formation of filamentous cellular inclusions, is a hallmark of neurodegenerative disease with characteristic filament structures, or conformers, defining each proteinopathy. Here...
17.
White D, Stowell M
Front Synaptic Neurosci
. 2021 Oct;
13:740318.
PMID: 34616284
Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone, but disruptions in any one of these components can have devastating consequences for neuronal communication....
18.
Rahman M, Worrell B, Stowell M, Hibbs R
Methods Enzymol
. 2021 Jun;
653:189-206.
PMID: 34099171
Nicotinic acetylcholine receptors are members of the Cys-loop superfamily of pentameric ligand-gated ion channels. The electric organ of the Torpedo ray is extraordinarily rich in an acetylcholine receptor that is...
19.
Liu Y, Wan C, Rathore S, Stowell M, Yu H, Shen J
Cell Rep
. 2021 Jan;
34(2):108611.
PMID: 33440145
Intracellular vesicle fusion is catalyzed by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Vesicle-anchored v-SNAREs pair with target membrane-associated t-SNAREs to form trans-SNARE complexes, releasing free energy to drive membrane...
20.
Hark T, Rao N, Castillon C, Basta T, Smukowski S, Bao H, et al.
Cell Syst
. 2020 Dec;
12(2):141-158.e9.
PMID: 33326751
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer's disease (AD). To observe protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we performed pulse-chase proteomics on...