John P Mayer
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Explore the profile of John P Mayer including associated specialties, affiliations and a list of published articles.
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49
Citations
716
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Recent Articles
1.
Sanner K, Kawell S, Evans J, Elekovic V, Walz M, Joksimovic S, et al.
bioRxiv
. 2025 Jan;
PMID: 39868306
The Ca 3.2 isoform of T-type voltage-gated calcium channels plays a crucial role in regulating the excitability of nociceptive neurons; the endogenous molecules that modulate its activity, however, remain poorly...
2.
Park J, Li J, Mayer J, Ball K, Wu J, Hall C, et al.
Nat Commun
. 2022 Sep;
13(1):5594.
PMID: 36151101
Insulin receptor (IR) signaling defects cause a variety of metabolic diseases including diabetes. Moreover, inherited mutations of the IR cause severe insulin resistance, leading to early morbidity and mortality with...
3.
Li J, Park J, Mayer J, Webb K, Uchikawa E, Wu J, et al.
Nat Struct Mol Biol
. 2022 Apr;
29(4):357-368.
PMID: 35361965
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of...
4.
He R, Mowery S, Chabenne J, Finan B, Mayer J, DiMarchi R
Front Endocrinol (Lausanne)
. 2021 Sep;
12:693958.
PMID: 34484114
Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics. We report a convenient and rapid procedure for...
5.
DiMarchi R, Mayer J
J Med Chem
. 2021 Jun;
64(13):8939-8941.
PMID: 34133152
Basal glucose control is commonly maintained by a single, once-daily administration of insulin through subcutaneous injection or a continuous pump-infusion. Insulin icodec, a novel ultralong-acting lipidated analog validates the concept...
6.
Yang B, Gelfanov V, Perez-Tilve D, Dubois B, Rohlfs R, Levy J, et al.
J Med Chem
. 2021 Apr;
64(8):4697-4708.
PMID: 33821647
Antagonism of glucagon's biological action is a proven strategy for decreasing glucose in diabetic animals and patients. To achieve full, potent, and selective suppression, we chemically optimized N-terminally truncated glucagon...
7.
Kabotso D, Smiley D, Mayer J, Gelfanov V, Perez-Tilve D, DiMarchi R, et al.
J Med Chem
. 2020 May;
63(11):6134-6143.
PMID: 32406685
Native insulin is susceptible to biophysical aggregation and fibril formation, promoted by manual agitation and elevated temperatures. The safety of the drug and its application to alternative forms of administration...
8.
Brunel F, Mayer J, DiMarchi R
Future Med Chem
. 2020 Mar;
12(8):649-654.
PMID: 32180453
No abstract available.
9.
He R, Pan J, Mayer J, Liu F
Chembiochem
. 2019 Dec;
21(8):1101-1111.
PMID: 31886929
The disulfide bond plays an important role in biological systems. It defines global conformation, and ultimately the biological activity and stability of the peptide or protein. It is frequently present,...
10.
Chabenne J, Mroz P, Mayer J, DiMarchi R
J Med Chem
. 2019 Nov;
63(7):3447-3460.
PMID: 31774682
Glucagon counters insulin's effects on glucose metabolism and serves as a rescue medicine in the treatment of hypoglycemia. Acute hypoglycemia, a common occurrence in insulin-dependent diabetes, is the central obstacle...