Michael Gurevitz
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Explore the profile of Michael Gurevitz including associated specialties, affiliations and a list of published articles.
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58
Citations
1044
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Recent Articles
11.
Zhang J, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, et al.
J Biol Chem
. 2012 Jul;
287(36):30719-28.
PMID: 22761417
Activation of voltage-gated sodium (Na(v)) channels initiates and propagates action potentials in electrically excitable cells. β-Scorpion toxins, including toxin IV from Centruroides suffusus suffusus (CssIV), enhance activation of Na(V) channels....
12.
Gurevitz M
Toxicon
. 2012 Jun;
60(4):502-11.
PMID: 22694883
Scorpion alpha and beta toxins interact with voltage-gated sodium channels (Na(v)s) at two pharmacologically distinct sites. Alpha toxins bind at receptor site-3 and inhibit channel inactivation, whereas beta toxins bind...
13.
Moran Y, Genikhovich G, Gordon D, Wienkoop S, Zenkert C, Ozbek S, et al.
Proc Biol Sci
. 2011 Nov;
279(1732):1351-8.
PMID: 22048953
Jellyfish, hydras, corals and sea anemones (phylum Cnidaria) are known for their venomous stinging cells, nematocytes, used for prey and defence. Here we show, however, that the potent Type I...
14.
Wang J, Yarov-Yarovoy V, Kahn R, Gordon D, Gurevitz M, Scheuer T, et al.
Proc Natl Acad Sci U S A
. 2011 Aug;
108(37):15426-31.
PMID: 21876146
The α-scorpions toxins bind to the resting state of Na(+) channels and inhibit fast inactivation by interaction with a receptor site formed by domains I and IV. Mutants T1560A, F1610A,...
15.
Gur M, Kahn R, Karbat I, Regev N, Wang J, Catterall W, et al.
J Biol Chem
. 2011 Aug;
286(40):35209-17.
PMID: 21832067
Neurotoxin receptor site-3 at voltage-gated Na(+) channels is recognized by various peptide toxin inhibitors of channel inactivation. Despite extensive studies of the effects of these toxins, their mode of interaction...
16.
Zhang J, Yarov-Yarovoy V, Scheuer T, Karbat I, Cohen L, Gordon D, et al.
J Biol Chem
. 2011 Jul;
286(38):33641-51.
PMID: 21795675
Voltage-gated sodium (Na(v)) channels are the molecular targets of β-scorpion toxins, which shift the voltage dependence of activation to more negative membrane potentials by a voltage sensor-trapping mechanism. Molecular determinants...
17.
Marcus Y, Altman-Gueta H, Wolff Y, Gurevitz M
J Exp Bot
. 2011 May;
62(12):4173-82.
PMID: 21551078
Orthophosphate (Pi) stimulates the activation of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) while paradoxically inhibiting its catalysis. Of three Pi-binding sites, the roles of the 5P- and latch sites have been documented, whereas...
18.
Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, et al.
J Biol Chem
. 2011 Apr;
286(18):15781-8.
PMID: 21454658
Scorpion β-toxins bind to the extracellular regions of the voltage-sensing module of domain II and to the pore module of domain III in voltage-gated sodium channels and enhance channel activation...
19.
Karbat I, Ilan N, Zhang J, Cohen L, Kahn R, Benveniste M, et al.
J Biol Chem
. 2010 Aug;
285(40):30531-8.
PMID: 20682774
Scorpion β-toxin 4 from Centruroides suffusus suffusus (Css4) enhances the activation of voltage-gated sodium channels through a voltage sensor trapping mechanism by binding the activated state of the voltage sensor...
20.
Paldi T, Gurevitz M
Biophys J
. 2010 Jul;
99(2):456-63.
PMID: 20643063
The voltage sensor is a four-transmembrane helix bundle (S1-S4) that couples changes in membrane potential to conformational alterations in voltage-gated ion channels leading to pore opening and ion conductance. Although...