Michael Goedken
Overview
Explore the profile of Michael Goedken including associated specialties, affiliations and a list of published articles.
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30
Citations
401
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Recent Articles
1.
Asby S, Asby S, Thompson L, Goedken M, Lucia S, Dominguez A, et al.
Kidney Int
. 2025 Feb;
PMID: 39922378
While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, they can elicit organ-related immune-related adverse events (irAEs) such as kidney injury. Here, our study evaluated the ability of a humanized...
2.
Toth E, Li H, Frost K, Sample P, Jilek J, Greenfield S, et al.
Acta Pharm Sin B
. 2024 Dec;
14(11):4874-4882.
PMID: 39664440
Hepatocyte hopping is the hepatocyte-to-sinusoid-to-hepatocyte shuttling that increases the efficiency of hepatic elimination of xenobiotics. This phenomenon is mediated efflux of hepatic metabolites by Mrp3 and reuptake by Oatp transporters...
3.
Lim J, Goedken M, Jin Y, Gu H, Cui J
Toxicol Sci
. 2024 Apr;
200(1):114-136.
PMID: 38648751
Polybrominated diphenyl ethers (PBDEs) are legacy flame retardants that bioaccumulate in the environment. The gut microbiome is an important regulator of liver functions including xenobiotic biotransformation and immune regulation. We...
4.
Wolff K, Robinson K, Suh N, Michniak-Kohn B, Goedken M, Polunas M, et al.
Phytomed Plus
. 2023 Dec;
3(4).
PMID: 38037612
Background: Moringa ( Lam.) seed extract (MSE) and its primary bioactive compound, moringa isothiocyanate-1(MIC-1), mitigate inflammation, oxidative stress, diabetes, and cancer in the rodent models following oral application. Purpose: To...
5.
Sarwar M, Cheng D, Peter R, Shannar A, Chou P, Wang L, et al.
Eur J Pharmacol
. 2023 Jun;
953:175866.
PMID: 37331680
Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the United States. Emerging evidence suggests that mitochondrial metabolism and epigenetics play an important role in the...
6.
Murray A, Banota T, Guo G, Smith L, Meshanni J, Lee J, et al.
Toxicol Appl Pharmacol
. 2022 Aug;
454:116208.
PMID: 35998709
Nitrogen mustard (NM) is a cytotoxic vesicant known to cause acute lung injury which progresses to fibrosis; this is associated with a sequential accumulation of pro- and anti-inflammatory macrophages in...
7.
Jilek J, Frost K, Jacobus K, He W, Toth E, Goedken M, et al.
Acta Pharm Sin B
. 2022 Jan;
11(12):3869-3878.
PMID: 35024313
Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal...
8.
Rizzolo D, Kong B, Taylor R, Brinker A, Goedken M, Buckley B, et al.
Acta Pharm Sin B
. 2022 Jan;
11(12):3847-3856.
PMID: 35024311
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different...
9.
Jilek J, Frost K, Marie S, Myers C, Goedken M, Wright S, et al.
Drug Metab Dispos
. 2021 Dec;
50(10):1389-1395.
PMID: 34921099
Ochratoxin A (OTA) is an abundant mycotoxin, yet the toxicological impact of its disposition is not well studied. OTA is an organic anion transporter (OAT) substrate primarily excreted in urine...
10.
Marques E, Agudelo J, Kaye E, Modaresi S, Pfohl M, Becanova J, et al.
Toxicology
. 2021 Aug;
462:152921.
PMID: 34464680
Per- and polyfluoroalkyl substances (PFAS) are a family of chemicals that are ubiquitous in the environment. Some of these chemicals, such as perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonate (PFHxS) and perfluorooctanoic acid...