Michael Goedken
Overview
Explore the profile of Michael Goedken including associated specialties, affiliations and a list of published articles.
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30
Citations
401
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Recent Articles
11.
Kim S, Choi S, Dutta M, Asubonteng J, Polunas M, Goedken M, et al.
Biochem Pharmacol
. 2021 Jul;
193:114698.
PMID: 34303710
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease due to the current epidemics of obesity and diabetes. The pregnane X receptor (PXR) is a xenobiotic-sensing nuclear...
12.
Pfohl M, Marques E, Auclair A, Barlock B, Jamwal R, Goedken M, et al.
Toxicol Sci
. 2021 Jan;
180(2):277-294.
PMID: 33483757
Perfluoroalkyl substances (PFAS) are a family of toxicants universally detected in human serum and known to cause dyslipidemia in animals and humans. Hepatic steatosis, which is defined as lipid deposition...
13.
Pfohl M, DaSilva N, Marques E, Agudelo J, Liu C, Goedken M, et al.
Int J Food Sci Nutr
. 2020 Nov;
72(4):499-510.
PMID: 33203257
Diets rich in fats are linked to elevated systemic inflammation, which augments the progression of inflammatory-related disorders including non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. A phenolic-enriched pomegranate fruit...
14.
Arman T, Lynch K, Goedken M, Clarke J
Chemosphere
. 2020 Nov;
269:128773.
PMID: 33143886
Microcystin-LR (MCLR) is a liver and kidney toxin produced by cyanobacteria. Recently, it was demonstrated that MCLR exposure drives the progression of high fat/high cholesterol (HFHC) induced nonalcoholic fatty liver...
15.
Marques E, Pfohl M, Auclair A, Jamwal R, Barlock B, Sammoura F, et al.
Toxicol Appl Pharmacol
. 2020 Sep;
408:115250.
PMID: 32979393
Hepatic steatosis increases risk of fatty liver and cardiovascular disease. Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has been used in industrial and commercial applications. PFOS administration induces...
16.
Aijaz A, Teryek M, Goedken M, Polunas M, Olabisi R
Cell Mol Bioeng
. 2019 Nov;
12(5):481-493.
PMID: 31719928
Introduction: We previously demonstrated that insulin secreting cells (ISCs) accelerate healing of chronic wounds, and it is known that mesenchymal stem cells (MSCs) also accelerate wound healing. Here, we report...
17.
Sunil V, Vayas K, Abramova E, Rancourt R, Cervelli J, Malaviya R, et al.
Toxicol Appl Pharmacol
. 2019 Nov;
387:114798.
PMID: 31678244
Nitrogen mustard (NM) is a cytotoxic vesicant known to cause acute lung injury which progresses to fibrosis. Herein, we developed a murine model of NM-induced pulmonary toxicity with the goal...
18.
Malekshah O, Sarkar S, Nomani A, Patel N, Javidian P, Goedken M, et al.
J Control Release
. 2019 Sep;
311-312:273-287.
PMID: 31499084
The objective of this study was to develop a stem cell-based system for targeted suicide gene therapy of recurrent, metastatic, and unresectable ovarian cancer. Malignant cells were obtained from the...
19.
Arman T, Lynch K, Montonye M, Goedken M, Clarke J
Toxins (Basel)
. 2019 Jul;
11(7).
PMID: 31323923
Microcystin-LR (MCLR) is a hepatotoxic cyanotoxin reported to cause a phenotype similar to nonalcoholic steatohepatitis (NASH). NASH is a common progressive liver disease that advances in severity due to exogenous...
20.
Schumacher J, Kong B, Wu J, Rizzolo D, Armstrong L, Chow M, et al.
Hepatology
. 2019 Jun;
71(2):670-685.
PMID: 31206730
Farnesoid X receptor (FXR) induces fibroblast growth factor 15 (FGF15; human ortholog FGF19) in the gut to potently inhibit bile acid (BA) synthesis in the liver. FXR activation in hepatic...