Michael F Freeman
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Explore the profile of Michael F Freeman including associated specialties, affiliations and a list of published articles.
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30
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611
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Recent Articles
1.
Crone K, Labonte J, Elias M, Freeman M
Protein Sci
. 2025 Jan;
34(2):e70021.
PMID: 39840790
N-Methylation of the peptide backbone confers pharmacologically beneficial characteristics to peptides that include greater membrane permeability and resistance to proteolytic degradation. The borosin family of ribosomally synthesized and post-translationally modified...
2.
Lee A, Carter R, Imani A, Dommaraju S, Hudson G, Mitchell D, et al.
ACS Chem Biol
. 2024 May;
19(5):1116-1124.
PMID: 38695893
Borosins are ribosomally synthesized and post-translationally modified peptides (RiPPs) containing backbone α--methylations. These modifications confer favorable pharmacokinetic properties including increased membrane permeability and resistance to proteolytic degradation. Previous studies have...
3.
Lee A, Carter R, Imani A, Dommaraju S, Hudson G, Mitchell D, et al.
bioRxiv
. 2024 Jan;
PMID: 38260703
Borosins are ribosomally synthesized and post-translationally modified peptides containing backbone α- -methylations. Identification of borosin precursor peptides is difficult because (1) there are no conserved sequence elements among borosin precursor...
4.
Gupta V, Bakshi U, Chang D, Lee A, Davis 3rd J, Chandrasekaran S, et al.
mSystems
. 2022 Nov;
7(6):e0092522.
PMID: 36378489
Biosynthetic gene clusters (BGCs) in microbial genomes encode bioactive secondary metabolites (SMs), which can play important roles in microbe-microbe and host-microbe interactions. Given the biological significance of SMs and the...
5.
Imani A, Lee A, Vishwanathan N, de Waal F, Freeman M
ACS Chem Biol
. 2022 Mar;
17(4):908-917.
PMID: 35297605
Borosins are ribosomally synthesized and post-translationally modified peptides (RiPPs) with α--methylations installed on the peptide backbone that impart unique properties like proteolytic stability to these natural products. The borosin RiPP...
6.
Miller F, Crone K, Jensen M, Shaw S, Harcombe W, Elias M, et al.
Nat Commun
. 2021 Sep;
12(1):5355.
PMID: 34504067
Peptide backbone α-N-methylations change the physicochemical properties of amide bonds to provide structural constraints and other favorable characteristics including biological membrane permeability to peptides. Borosin natural product pathways are the...
7.
Matabaro E, Song H, Chepkirui C, Kaspar H, Witte L, Naismith J, et al.
Methods Enzymol
. 2021 Jul;
656:429-458.
PMID: 34325794
Backbone N-methylation as a posttranslational modification was recently discovered in a class of ribosomally encoded peptides referred to as borosins. The founding members of the borosins are the omphalotins (A-I),...
8.
Rust M, Helfrich E, Freeman M, Nanudorn P, Field C, Ruckert C, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(17):9508-9518.
PMID: 32291345
Bacterial specialized metabolites are increasingly recognized as important factors in animal-microbiome interactions: for example, by providing the host with chemical defenses. Even in chemically rich animals, such compounds have been...
9.
Bhushan A, Egli P, Peters E, Freeman M, Piel J
Nat Chem
. 2019 Sep;
11(10):931-939.
PMID: 31501509
The polytheonamides are among the most complex and biosynthetically distinctive natural products known to date. These potent peptide cytotoxins are derived from a ribosomal precursor processed by 49 mostly non-canonical...
10.
Quijano M, Zach C, Miller F, Lee A, Imani A, Kunzler M, et al.
J Am Chem Soc
. 2019 May;
141(24):9637-9644.
PMID: 31117659
Backbone N-methylations impart several favorable characteristics to peptides including increased proteolytic stability and membrane permeability. Nonetheless, amide bond N-methylations incorporated as post-translational modifications are scarce in nature and were first...