Michael F Freeman
Overview
Explore the profile of Michael F Freeman including associated specialties, affiliations and a list of published articles.
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30
Citations
611
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0
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Recent Articles
11.
Helf M, Freeman M, Piel J
J Ind Microbiol Biotechnol
. 2019 Jan;
46(3-4):551-563.
PMID: 30627933
Polytheonamides are the most extensively modified ribosomally synthesized and post-translationally modified peptide natural products (RiPPs) currently known. In RiPP biosynthesis, the processed peptide is usually released from a larger precursor...
12.
Song H, van der Velden N, Shiran S, Bleiziffer P, Zach C, Sieber R, et al.
Sci Adv
. 2018 Aug;
4(8):eaat2720.
PMID: 30151425
The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of...
13.
Imani A, Freeman M
Synth Syst Biotechnol
. 2018 Jun;
3(2):81-82.
PMID: 29900419
No abstract available.
14.
Cobalamin-Dependent C-Methyltransferases From Marine Microbes: Accessibility via Rhizobia Expression
Freeman M
Methods Enzymol
. 2018 May;
604:259-286.
PMID: 29779655
Cobalamin-dependent radical S-adenosylmethionine (rSAM) methyltransferases catalyze chemically challenging methylation reactions on diverse natural products at unactivated carbon centers. In vivo reconstitution and biosynthetic studies of natural product gene clusters encoding...
15.
van der Velden N, Kalin N, Helf M, Piel J, Freeman M, Kunzler M
Nat Chem Biol
. 2017 Jun;
13(8):833-835.
PMID: 28581484
Peptide backbone N-methylation, as seen in cyclosporin A, has been considered to be exclusive to nonribosomal peptides. We have identified the first post-translationally modified peptide or protein harboring internal α-N-methylations...
16.
Freeman M, Helf M, Bhushan A, Morinaka B, Piel J
Nat Chem
. 2017 Mar;
9(4):387-395.
PMID: 28338684
Uncultivated bacteria represent a massive resource of new enzymes and bioactive metabolites, but such bacteria remain functionally enigmatic. Polytheonamides are potent peptide cytotoxins produced by uncultivated bacteria that exist as...
17.
Morinaka B, Verest M, Freeman M, Gugger M, Piel J
Angew Chem Int Ed Engl
. 2016 Dec;
56(3):762-766.
PMID: 27958669
Radical S-adenosyl methionine peptide epimerases (RSPEs) are an enzyme family that accomplishes regiospecific and irreversible introduction of multiple d-configured residues into ribosomally encoded peptides. Collectively, RSPEs can generate diverse epimerization...
18.
Freeman M, Vagstad A, Piel J
Curr Opin Chem Biol
. 2015 Dec;
31:8-14.
PMID: 26625171
The vast majority of microorganisms on the planet have not been grown under laboratory conditions due to unknown metabolic and environmental constraints. This uncultivated majority has enormous potential as a...
19.
Morinaka B, Vagstad A, Helf M, Gugger M, Kegler C, Freeman M, et al.
Angew Chem Int Ed Engl
. 2014 Jun;
53(32):8503-7.
PMID: 24943072
PoyD is a radical S-adenosyl methionine epimerase that introduces multiple D-configured amino acids at alternating positions into the highly complex marine peptides polytheonamide A and B. This novel post-translational modification...
20.
Buller A, Freeman M, Schildbach J, Townsend C
Biochemistry
. 2014 Jun;
53(26):4273-81.
PMID: 24933323
In the past decade, there have been major achievements in understanding the relationship between enzyme catalysis and protein structural plasticity. In autoprocessing systems, however, there is a sparsity of direct...