Michael E Pique
Overview
Explore the profile of Michael E Pique including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
1775
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0
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Recent Articles
1.
Roberts V, Pique M, Hsu S, Li S
Biochemistry
. 2017 Nov;
56(48):6329-6342.
PMID: 29099587
Protein-protein interactions are essential for biological function, but structures of protein-protein complexes are difficult to obtain experimentally. To derive the protein complex of the DNA-repair enzyme human uracil-DNA-glycosylase (hUNG) with...
2.
Naughton K, Phan L, Leung E, Kautz R, Lin Q, Van Dyke Y, et al.
Adv Mater
. 2016 Jul;
28(38):8405-8412.
PMID: 27454809
Films from the cephalopod protein reflectin demonstrate multifaceted functionality as infrared camouflage coatings, proton transport media, and substrates for growth of neural stem cells. A detailed study of the in...
3.
Forli S, Huey R, Pique M, Sanner M, Goodsell D, Olson A
Nat Protoc
. 2016 Apr;
11(5):905-19.
PMID: 27077332
Computational docking can be used to predict bound conformations and free energies of binding for small-molecule ligands to macromolecular targets. Docking is widely used for the study of biomolecular interactions...
4.
Roberts V, Pique M, Ten Eyck L, Li S
Proteins
. 2013 Aug;
81(12):2106-18.
PMID: 23966176
Protein-DNA interactions are essential for many biological processes. X-ray crystallography can provide high-resolution structures, but protein-DNA complexes are difficult to crystallize and typically contain only small DNA fragments. Thus, there...
5.
Roberts V, Thompson E, Pique M, Perez M, Ten Eyck L
J Comput Chem
. 2013 May;
34(20):1743-58.
PMID: 23695987
Computational docking is a useful tool for predicting macromolecular complexes, which are often difficult to determine experimentally. Here, we present the DOT2 software suite, an updated version of the DOT...
6.
Roberts V, Pique M, Hsu S, Li S, Slupphaug G, Rambo R, et al.
Nucleic Acids Res
. 2012 Apr;
40(13):6070-81.
PMID: 22492624
X-ray crystallography provides excellent structural data on protein-DNA interfaces, but crystallographic complexes typically contain only small fragments of large DNA molecules. We present a new approach that can use longer...
7.
Trinh M, Odorico M, Pique M, Teulon J, Roberts V, Ten Eyck L, et al.
Structure
. 2012 Jan;
20(1):113-20.
PMID: 22244760
Classical structural biology techniques face a great challenge to determine the structure at the atomic level of large and flexible macromolecules. We present a novel methodology that combines high-resolution AFM...
8.
Hammel M, Rey M, Yu Y, Mani R, Classen S, Liu M, et al.
J Biol Chem
. 2011 Jul;
286(37):32638-50.
PMID: 21775435
The XRCC4-like factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for DNA double strand breaks in human cells. Yet, how XLF binds XRCC4 and impacts...
9.
Li J, Lim M, Li S, Brock M, Pique M, Woods Jr V, et al.
Structure
. 2008 Jan;
16(1):137-48.
PMID: 18184591
The bacterial pathogen Vibrio cholerae uses toxin-coregulated pili (TCP) to colonize the human intestine, causing the severe diarrheal disease cholera. TCP are long, thin, flexible homopolymers of the TcpA subunit...
10.
Manayani D, Thomas D, Dryden K, Reddy V, Siladi M, Marlett J, et al.
PLoS Pathog
. 2007 Oct;
3(10):1422-31.
PMID: 17922572
The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B. anthracis produces an...