Andrew S Arvai
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Explore the profile of Andrew S Arvai including associated specialties, affiliations and a list of published articles.
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41
Citations
2953
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Recent Articles
1.
Babu Chinnam N, Thapar R, Arvai A, Sarker A, Soll J, Paul T, et al.
J Biol Chem
. 2024 May;
300(6):107368.
PMID: 38750793
Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with regulating splicing, transcriptional, and...
2.
Longo M, Roy S, Chen Y, Tomaszowski K, Arvai A, Pepper J, et al.
Nat Commun
. 2023 Jul;
14(1):4445.
PMID: 37488098
RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer. Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysis. Here...
3.
Nguyen M, Moiani D, Ahmed Z, Arvai A, Namjoshi S, Shin D, et al.
Prog Biophys Mol Biol
. 2021 Mar;
163:143-159.
PMID: 33675849
Human uracil DNA-glycosylase (UDG) is the prototypic and first identified DNA glycosylase with a vital role in removing deaminated cytosine and incorporated uracil and 5-fluorouracil (5-FU) from DNA. UDG depletion...
4.
Wilson 3rd D, Deacon A, Duncton M, Pellicena P, Georgiadis M, Yeh A, et al.
Prog Biophys Mol Biol
. 2020 Oct;
163:130-142.
PMID: 33115610
Cancer will directly affect the lives of over one-third of the population. The DNA Damage Response (DDR) is an intricate system involving damage recognition, cell cycle regulation, DNA repair, and...
5.
Tsutakawa S, Sarker A, Ng C, Arvai A, Shin D, Shih B, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(25):14127-14138.
PMID: 32522879
Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA damage responses (DDR) and a pathway coordinator and structure-specific endonuclease in nucleotide excision repair (NER). Different...
6.
Tsutakawa S, Thompson M, Arvai A, Neil A, Shaw S, Algasaier S, et al.
Nat Commun
. 2019 Jul;
8:16145.
PMID: 31305777
[This corrects the article DOI: 10.1038/ncomms15855.].
7.
Moiani D, Ronato D, Brosey C, Arvai A, Syed A, Masson J, et al.
Methods Enzymol
. 2018 Mar;
601:205-241.
PMID: 29523233
For inhibitor design, as in most research, the best system is question dependent. We suggest structurally defined allostery to design specific inhibitors that target regions beyond active sites. We choose...
8.
Tsutakawa S, Thompson M, Arvai A, Neil A, Shaw S, Algasaier S, et al.
Nat Commun
. 2017 Jun;
8:15855.
PMID: 28653660
DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5'-flaps one nucleotide into...
9.
Chaudhury P, Neiner T, DImprima E, Banerjee A, Reindl S, Ghosh A, et al.
Mol Microbiol
. 2015 Oct;
99(4):674-85.
PMID: 26508112
The motor of the membrane-anchored archaeal motility structure, the archaellum, contains FlaX, FlaI and FlaH. FlaX forms a 30 nm ring structure that acts as a scaffold protein and was...
10.
Banerjee A, Tsai C, Chaudhury P, Tripp P, Arvai A, Ishida J, et al.
Structure
. 2015 Apr;
23(5):863-872.
PMID: 25865246
Archaea employ the archaellum, a type IV pilus-like nanomachine, for swimming motility. In the crenarchaeon Sulfolobus acidocaldarius, the archaellum consists of seven proteins: FlaB/X/G/F/H/I/J. FlaF is conserved and essential for...