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Michael D Rosenblum

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Articles 96
Citations 6116
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Recent Articles
1.
Mahuron K, Shahid O, Sao P, Wu C, Haugh A, Huppert L, et al.
Cancer Res . 2025 Mar; PMID: 40042995
PD-1 pathway inhibitors have revolutionized cancer therapy. However, most patients do not durably benefit, highlighting the need for biomarkers to stratify patients as responders or non-responders. While CD8+ tumor infiltrating...
2.
Leboit P, Patel D, Cohen J, Moss M, Naik H, Yates A, et al.
Exp Dermatol . 2025 Feb; 34(2):e70057. PMID: 39930604
Hidradenitis suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. Due to the relatively limited understanding of HS's pathogenesis, there are currently insufficient treatment options available, and...
3.
Merrill E, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells E, et al.
bioRxiv . 2025 Jan; PMID: 39868197
Public health alarm concerning the emerging fungus is fueled by its antifungal drug resistance and propensity to cause deadly outbreaks. Persistent skin colonization drives transmission and lethal sepsis although its...
4.
Macon C, Yang A, Patel D, North J, Rosenblum M, Cohen J
Exp Dermatol . 2024 Dec; 33(12):e70023. PMID: 39673225
Regulatory T cells (Tregs) are specialised T lymphocytes that sit at the nexus of immune regulation and tissue repair. While it is appreciated that a substantial number of Tregs are...
5.
Quandt Z, Jacob S, Fadlullah M, Wu C, Wu C, Huppert L, et al.
BJC Rep . 2024 Nov; 2(1):46. PMID: 39516257
Objective: Many patients with melanoma treated with immune checkpoint inhibitors (ICIs) do not derive response. Preclinical and retrospective studies identified that inhibition of the cyclooxygenase (COX) pathway may improve response...
6.
Sommer C, Cohen J, Dehmel S, Neuhaus V, Schaudien D, Braun A, et al.
Eur J Immunol . 2024 Mar; 54(4):e2350580. PMID: 38430129
Recombinant human IL-2 has been used to treat inflammatory diseases and cancer; however, side effects like skin rashes limit the use of this therapeutic. To identify key molecules and cells...
7.
Cohen J, Gouirand V, Macon C, Lowe M, Boothby I, Moreau J, et al.
Sci Immunol . 2024 Jan; 9(91):eadh0152. PMID: 38181095
Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in these tissues. We developed...
8.
Lowe M, Cohen J, Moss M, Clancy S, Adler J, Yates A, et al.
JCI Insight . 2023 Dec; 9(3). PMID: 38113104
Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B...
9.
Lowe M, Cohen J, Moss M, Clancy S, Adler J, Yates A, et al.
bioRxiv . 2023 Feb; PMID: 36824918
Background: Hidradenitis suppurativa (HS) skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component of this immune milieu...
10.
Lowe M, Naik H, Clancy S, Pauli M, Smith K, Bi Y, et al.
JCI Insight . 2022 Oct; 7(20). PMID: 36278491
No abstract available.