Margaret M Lowe
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Explore the profile of Margaret M Lowe including associated specialties, affiliations and a list of published articles.
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28
Citations
1475
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Recent Articles
1.
Mahuron K, Shahid O, Sao P, Wu C, Haugh A, Huppert L, et al.
Cancer Res
. 2025 Mar;
PMID: 40042995
PD-1 pathway inhibitors have revolutionized cancer therapy. However, most patients do not durably benefit, highlighting the need for biomarkers to stratify patients as responders or non-responders. While CD8+ tumor infiltrating...
2.
Leboit P, Patel D, Cohen J, Moss M, Naik H, Yates A, et al.
Exp Dermatol
. 2025 Feb;
34(2):e70057.
PMID: 39930604
Hidradenitis suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. Due to the relatively limited understanding of HS's pathogenesis, there are currently insufficient treatment options available, and...
3.
Cohen J, Gouirand V, Macon C, Lowe M, Boothby I, Moreau J, et al.
Sci Immunol
. 2024 Jan;
9(91):eadh0152.
PMID: 38181095
Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in these tissues. We developed...
4.
Lowe M, Cohen J, Moss M, Clancy S, Adler J, Yates A, et al.
JCI Insight
. 2023 Dec;
9(3).
PMID: 38113104
Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B...
5.
Lowe M, Cohen J, Moss M, Clancy S, Adler J, Yates A, et al.
bioRxiv
. 2023 Feb;
PMID: 36824918
Background: Hidradenitis suppurativa (HS) skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component of this immune milieu...
6.
Lowe M, Naik H, Clancy S, Pauli M, Smith K, Bi Y, et al.
JCI Insight
. 2022 Oct;
7(20).
PMID: 36278491
No abstract available.
7.
Moss M, Pauli M, Moreau J, Cohen J, Rosenblum M, Lowe M
J Vis Exp
. 2022 Jul;
(184).
PMID: 35848826
The human skin xenograft model, in which human donor skin is transplanted onto an immunodeficient mouse host, is an important option for translational research in skin immunology. Murine and human...
8.
Boothby I, Kinet M, Boda D, Kwan E, Clancy S, Cohen J, et al.
Nature
. 2021 Oct;
599(7886):667-672.
PMID: 34707292
Inflammation early in life can prime the local immune milieu of peripheral tissues, which can cause lasting changes in immunological tone that confer disease protection or susceptibility. The cellular and...
9.
Mehta P, Gouirand V, Boda D, Zhang J, Gearty S, Zirak B, et al.
J Immunol
. 2021 Sep;
207(7):1763-1775.
PMID: 34470859
Regulatory T cells (Tregs) reside in nonlymphoid tissues where they carry out unique functions. The molecular mechanisms responsible for Treg accumulation and maintenance in these tissues are relatively unknown. Using...
10.
Moreau J, Dhariwala M, Gouirand V, Boda D, Boothby I, Lowe M, et al.
Sci Immunol
. 2021 Aug;
6(62).
PMID: 34452925
Regulatory T cells (T) use multiple mechanisms to attenuate inflammation and prevent autoimmunity. T residing in peripheral (i.e., nonlymphoid) tissues have specialized functions; specifically, skin T promote wound healing, suppress...