Michael D Rosenblum
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Explore the profile of Michael D Rosenblum including associated specialties, affiliations and a list of published articles.
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96
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6116
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Recent Articles
11.
Moss M, Pauli M, Moreau J, Cohen J, Rosenblum M, Lowe M
J Vis Exp
. 2022 Jul;
(184).
PMID: 35848826
The human skin xenograft model, in which human donor skin is transplanted onto an immunodeficient mouse host, is an important option for translational research in skin immunology. Murine and human...
12.
Liu J, Chang H, Grewal R, Cummins D, Bui A, Beck K, et al.
JID Innov
. 2022 Jun;
2(3):100094.
PMID: 35757784
The IL-17A inhibitor secukinumab is efficacious for the treatment of psoriasis. To better understand its mechanism of action, we investigated its impact on psoriatic lesions from 15 patients with moderate-to-severe...
13.
Moreau J, Velegraki M, Bolyard C, Rosenblum M, Li Z
Sci Immunol
. 2022 Mar;
7(69):eabi4613.
PMID: 35302863
Transforming growth factor-β1 (TGF-β1) is inextricably linked to regulatory T cell (T) biology. However, precisely untangling the role for TGF-β1 in T differentiation and function is complicated by the pleiotropic...
14.
Gouirand V, Rosenblum M
Sci Immunol
. 2022 Mar;
7(69):eabo6765.
PMID: 35245088
MTHFD2 is a metabolic checkpoint of T cell fate and function.
15.
Glasgow J, Byrnes J, Barbee S, Moreau J, Rosenblum M, Wells J
Cell Chem Biol
. 2022 Feb;
29(4):597-604.e7.
PMID: 35104453
Layilin is a small type I transmembrane receptor thought to bridge extracellular ligands with the cytoskeleton through its intracellular interactions with the scaffolding protein talin. Recent bulk- and single-cell RNA...
16.
Moreau J, Gouirand V, Rosenblum M
JID Innov
. 2022 Jan;
1(2):100014.
PMID: 35024681
The diverse populations of tissue-resident and transitory T cells present in the skin share a common functional need to enter, traverse, and interact with their environment. These processes are largely...
17.
Boothby I, Kinet M, Boda D, Kwan E, Clancy S, Cohen J, et al.
Nature
. 2021 Oct;
599(7886):667-672.
PMID: 34707292
Inflammation early in life can prime the local immune milieu of peripheral tissues, which can cause lasting changes in immunological tone that confer disease protection or susceptibility. The cellular and...
18.
Gouirand V, Rosenblum M
Sci Immunol
. 2021 Oct;
6(64):eabm5116.
PMID: 34597122
Regulatory T cells can function in and reverse established autoimmunity.
19.
Mehta P, Gouirand V, Boda D, Zhang J, Gearty S, Zirak B, et al.
J Immunol
. 2021 Sep;
207(7):1763-1775.
PMID: 34470859
Regulatory T cells (Tregs) reside in nonlymphoid tissues where they carry out unique functions. The molecular mechanisms responsible for Treg accumulation and maintenance in these tissues are relatively unknown. Using...
20.
Moreau J, Dhariwala M, Gouirand V, Boda D, Boothby I, Lowe M, et al.
Sci Immunol
. 2021 Aug;
6(62).
PMID: 34452925
Regulatory T cells (T) use multiple mechanisms to attenuate inflammation and prevent autoimmunity. T residing in peripheral (i.e., nonlymphoid) tissues have specialized functions; specifically, skin T promote wound healing, suppress...