Michael C Wehr
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Explore the profile of Michael C Wehr including associated specialties, affiliations and a list of published articles.
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34
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1183
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Recent Articles
1.
Borsdorf S, Zeug A, Wu Y, Mitroshina E, Vedunova M, Gaitonde S, et al.
Cell Commun Signal
. 2024 Nov;
22(1):563.
PMID: 39580460
Background: Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an interaction between the serotonin receptor 7 (5-HT7R),...
2.
Popovic L, Brankatschk B, Palladino G, Rossner M, Wehr M
Biomed Pharmacother
. 2024 Oct;
180:117523.
PMID: 39405910
Selectivity profiling is key for assessing the pharmacological properties of multi-target drugs. We have developed a cell-based and barcoded assay encompassing ten druggable targets, including G protein-coupled receptors (GPCRs), receptor...
3.
Wu Y, Jensen N, Rossner M, Wehr M
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791511
G protein-coupled receptors (GPCRs) are relevant targets for health and disease as they regulate various aspects of metabolism, proliferation, differentiation, and immune pathways. They are implicated in several disease areas,...
4.
Stepan J, Heinz D, Dethloff F, Wiechmann S, Martinelli S, Hafner K, et al.
Sci Signal
. 2024 Apr;
17(834):eadj6603.
PMID: 38687825
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an...
5.
Popovic L, Rossner M, Wehr M
STAR Protoc
. 2024 Apr;
5(2):102987.
PMID: 38635397
The ERBBprofiler assay measures compound effects on ERBB family receptors and key downstream signaling pathways that are implicated in cancer or other complex diseases. Here, we present a protocol for...
6.
Popovic L, Wintgens J, Wu Y, Brankatschk B, Menninger S, Degenhart C, et al.
iScience
. 2024 Feb;
27(2):108839.
PMID: 38303712
ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target ERBB receptors, the next generation of drugs requires enhanced...
7.
Raabe F, Hausruckinger A, Gagliardi M, Ahmad R, Almeida V, Galinski S, et al.
bioRxiv
. 2024 Jan;
PMID: 38260577
Schizophrenia (SCZ) is a genetically heterogenous psychiatric disorder of highly polygenic nature. Correlative evidence from genetic studies indicate that the aggregated effects of distinct genetic risk factor combinations found in...
8.
Huhne-Landgraf A, Laurent K, Frisch M, Wehr M, Rossner M, Landgraf D
Biol Psychiatry Glob Open Sci
. 2023 Oct;
3(4):632-641.
PMID: 37881564
Background: Psychiatric and metabolic disorders occur disproportionately often comorbidly, which poses particular hurdles for patients and therapists. However, the mechanisms that promote such comorbidities are largely unknown and therefore cannot...
9.
Ma X, Mandausch F, Wu Y, Sahoo V, Ma W, Leoni G, et al.
Cell Signal
. 2023 Oct;
113:110917.
PMID: 37813295
The conserved Hippo signalling pathway plays a crucial role in tumour formation by limiting tissue growth and proliferation. At the core of this pathway are tumour suppressor kinases STK3/4 and...
10.
Wu Y, von Hauff I, Jensen N, Rossner M, Wehr M
Biosensors (Basel)
. 2023 Jan;
13(1).
PMID: 36671883
G protein-coupled receptors (GPCRs) are major disease-relevant drug targets; robust monitoring of their activities upon drug treatment is key to drug discovery. The split TEV cell-based assay technique monitors the...