Michael C Wehr
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Explore the profile of Michael C Wehr including associated specialties, affiliations and a list of published articles.
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34
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1183
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Recent Articles
11.
Stepan J, Heinz D, Dethloff F, Bajaj T, Zellner A, Hafner K, et al.
Cell Rep
. 2022 Dec;
41(10):111766.
PMID: 36476872
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing protein 1 (WWC1)...
12.
Raabe F, Stephan M, Waldeck J, Huber V, Demetriou D, Kannaiyan N, et al.
Cells
. 2022 Jan;
11(2).
PMID: 35053357
Oligodendrocytes (OLs) are critical for myelination and are implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression of...
13.
Herholt A, Sahoo V, Popovic L, Wehr M, Rossner M
Curr Opin Chem Biol
. 2021 Oct;
66:102091.
PMID: 34644670
The power of next-generation sequencing has stimulated the development of many analysis techniques for transcriptomics and genomics. More recently, the concept of 'molecular barcoding' has broadened the spectrum of sequencing-based...
14.
Herholt A, Galinski S, Geyer P, Rossner M, Wehr M
Trends Pharmacol Sci
. 2020 Apr;
41(5):318-335.
PMID: 32223968
Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically...
15.
Hasan A, Roeh A, Leucht S, Langguth B, Hansbauer M, Oviedo-Salcedo T, et al.
Contemp Clin Trials Commun
. 2020 Feb;
17:100537.
PMID: 32072071
Background: Preclinical studies recently showed that the mineralocorticoid antagonist spironolactone acts also as an antagonist of the NRG1-ERBB4 signaling pathway and improves schizophrenia-like behaviour in Nrg1 transgenic mouse model. As...
16.
Wintgens J, Wichert S, Popovic L, Rossner M, Wehr M
Cell Mol Life Sci
. 2019 Aug;
76(19):3915.
PMID: 31377842
The article Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays, written by Jan P. Wintgens, Sven P. Wichert, Luksa Popovic, Moritz J....
17.
Wintgens J, Wichert S, Popovic L, Rossner M, Wehr M
Cell Mol Life Sci
. 2019 Jan;
76(6):1185-1199.
PMID: 30623207
Receptor tyrosine kinases (RTKs) play key roles in various aspects of cell biology, including cell-to-cell communication, proliferation and differentiation, survival, and tissue homeostasis, and have been implicated in various diseases...
18.
Herholt A, Brankatschk B, Kannaiyan N, Papiol S, Wichert S, Wehr M, et al.
Sci Rep
. 2018 Dec;
8(1):17597.
PMID: 30514868
Neuronal signal transduction shapes brain function and malfunction may cause mental disorders. Despite the existence of functional genomics screens for proliferation and toxicity, neuronal signalling has been difficult to address...
19.
Galinski S, Wichert S, Rossner M, Wehr M
Sci Rep
. 2018 May;
8(1):8137.
PMID: 29802268
G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors and are implicated in the physiological regulation of many biological processes. The high diversity of GPCRs and their...
20.
Wehr M, Hinrichs W, Brzozka M, Unterbarnscheidt T, Herholt A, Wintgens J, et al.
EMBO Mol Med
. 2017 Jul;
9(10):1448-1462.
PMID: 28743784
Enhanced NRG1-ERBB4 signaling is a risk pathway in schizophrenia, and corresponding mouse models display several endophenotypes of the disease. Nonetheless, pathway-directed treatment strategies with clinically applicable compounds have not been...