Michael C ODonovan
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Explore the profile of Michael C ODonovan including associated specialties, affiliations and a list of published articles.
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29637
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Recent Articles
11.
Legge S, Pardinas A, Woolway G, Rees E, Cardno A, Escott-Price V, et al.
JAMA Psychiatry
. 2024 Mar;
81(7):681-690.
PMID: 38536179
Importance: Large-scale biobanks provide important opportunities for mental health research, but selection biases raise questions regarding the comparability of individuals with those in clinical research settings. Objective: To compare the...
12.
Panagiotaropoulou G, Georgii Hellberg K, Coleman J, Seok D, Kalman J, Mitchell P, et al.
medRxiv
. 2024 Feb;
PMID: 38410442
Background: Accurate diagnosis of bipolar disorder (BD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A key reason is that...
13.
Kappel D, Rees E, Fenner E, King A, Jansen J, Helthuis M, et al.
Eur Neuropsychopharmacol
. 2024 Feb;
80:47-54.
PMID: 38310750
Clozapine is the only licensed medication for treatment-resistant schizophrenia (TRS). Few predictors for variation in response to clozapine have been identified, but clozapine metabolism is known to influence therapeutic response...
14.
Koch E, Pardinas A, OConnell K, Selvaggi P, Camacho Collados J, Babic A, et al.
Biol Psychiatry
. 2024 Jan;
96(7):543-551.
PMID: 38185234
Precision medicine has the ambition to improve treatment response and clinical outcomes through patient stratification and holds great potential for the treatment of mental disorders. However, several important factors are...
15.
Cameron D, Vinh N, Prapaiwongs P, Perry E, Walters J, Li M, et al.
medRxiv
. 2024 Jan;
PMID: 38168283
Background: The ganglionic eminences are fetal-specific structures that give rise to gamma-aminobutyric acid (GABA)- and acetylcholine- releasing neurons of the forebrain. Given evidence for GABAergic and cholinergic disturbances in schizophrenia,...
16.
Woolway G, Legge S, Lynham A, Smart S, Hubbard L, Daniel E, et al.
medRxiv
. 2023 Dec;
PMID: 38106032
Background: Diagnoses in psychiatric research can be derived from various sources. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia. Methods: The study included 3,029 clinically ascertained...
17.
Clifton N, Lin J, Holt C, ODonovan M, Mill J
Biol Psychiatry
. 2023 Dec;
95(9):888-895.
PMID: 38103876
Background: Genes that encode synaptic proteins or messenger RNA targets of the RNA-binding protein FMRP (fragile X messenger ribonucleoprotein) have been linked to schizophrenia and autism spectrum disorder (ASD) through...
18.
Wang S, Wang B, Drury V, Drake S, Sun N, Alkhairo H, et al.
Nat Commun
. 2023 Dec;
14(1):8077.
PMID: 38057346
Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity disorder (ADHD) display strong male sex bias, due to a combination of genetic and biological factors, as well as selective ascertainment....
19.
Shakeshaft A, Martin J, Dennison C, Riglin L, Lewis C, ODonovan M, et al.
Mol Psychiatry
. 2023 Nov;
29(2):238-246.
PMID: 37990052
Anxiety and depression (emotional disorders) are familial and heritable, especially when onset is early. However, other cross-generational studies suggest transmission of youth emotional problems is explained by mainly environmental risks....
20.
Owen M, Legge S, Rees E, Walters J, ODonovan M
Mol Psychiatry
. 2023 Oct;
28(9):3638-3647.
PMID: 37853064
There has been substantial progress in understanding the genetics of schizophrenia over the past 15 years. This has revealed a highly polygenic condition with the majority of the currently explained...