Valentina Escott-Price
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Explore the profile of Valentina Escott-Price including associated specialties, affiliations and a list of published articles.
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155
Citations
12033
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Recent Articles
1.
Barnett E, Hess J, Hou J, Escott-Price V, Fennema-Notestine C, Kremen W, et al.
medRxiv
. 2025 Mar;
PMID: 40061341
Background: Genetic risk factors for psychiatric and neurodegenerative disorders are well documented. However, some individuals with high genetic risk remain unaffected, and the mechanisms underlying such resilience remain poorly understood....
2.
Hardy J, Escott-Price V
Mol Psychiatry
. 2025 Jan;
PMID: 39880902
In this perspective we draw together the data from the genome wide association studies for Alzheimer's disease, Parkinson's disease and the tauopathies and reach the conclusion that in each case,...
3.
OConnell K, Koromina M, van der Veen T, Boltz T, David F, Yang J, et al.
Nature
. 2025 Jan;
PMID: 39843750
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants...
4.
Wills C, Watts K, Houseman A, Maughan T, Fisher D, Al-Tassan N, et al.
Sci Rep
. 2025 Jan;
15(1):2423.
PMID: 39827162
The location of a patient's colorectal cancer (CRC) influences their outcome but inherited factors may also be involved. We studied 1899 patients with advanced CRC (514 had proximal colonic, 493...
5.
Human longevity and Alzheimer's disease variants act via microglia and oligodendrocyte gene networks
Graham A, Bellou E, Harwood J, Yaman U, Celikag M, Magusali N, et al.
Brain
. 2025 Jan;
148(3):969-984.
PMID: 39778705
Ageing underlies functional decline of the brain and is the primary risk factor for several neurodegenerative conditions, including Alzheimer's disease (AD). However, the molecular mechanisms that cause functional decline of...
6.
Bellou E, Kim W, Leonenko G, Tao F, Simmonds E, Wu Y, et al.
Alzheimers Res Ther
. 2025 Jan;
17(1):6.
PMID: 39762974
Background: The success of selecting high risk or early-stage Alzheimer's disease individuals for the delivery of clinical trials depends on the design and the appropriate recruitment of participants. Polygenic risk...
7.
Chandler H, Wheeler J, Escott-Price V, Murphy K, Lancaster T
Alzheimers Dement
. 2024 Dec;
21(2):e14455.
PMID: 39737667
Introduction: White matter hyperintensity volumes (WMHVs) are disproportionally prevalent in individuals with Alzheimer's disease (AD), potentially reflecting neurovascular injury. We quantify the association between AD polygenic risk score (AD-PRS) and...
8.
Hou J, Hess J, Zhang C, van Rooij J, Hearn G, Fan C, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2024 Dec;
:e33019.
PMID: 39679839
The comprehensive genome-wide nature of transcriptome studies in Alzheimer's disease (AD) should provide a reliable description of disease molecular states. However, the genes and molecular systems nominated by transcriptomic studies...
9.
Woolway G, Legge S, Lynham A, Smart S, Hubbard L, Daniel E, et al.
Schizophrenia (Heidelb)
. 2024 Oct;
10(1):99.
PMID: 39477999
The increasing availability of biobanks is changing the way individuals are identified for genomic research. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia. The study included...
10.
Shitomi-Jones L, Dolman C, Jones I, Kirov G, Escott-Price V, Legge S, et al.
Nat Ment Health
. 2024 Oct;
2(10):1161-1168.
PMID: 39421137
Although the relationship between perimenopause and changes in mood has been well established, knowledge of risk of a broad spectrum of psychiatric disorders associated with reproductive aging is limited. Here...