Michael Buchert
Overview
Explore the profile of Michael Buchert including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
1081
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Recent Articles
1.
Halawani R, Buchert M, Chen Y
IEEE Rev Biomed Eng
. 2025 Mar;
PP.
PMID: 40030404
Genomics plays an essential role in the early detection, classification, and targeted cancer therapy based on the analysis of precise alterations at the molecular level. Using the most reliable approach...
2.
Haupt S, Carcel C, Halliday L, Billiards S, Carson L, Redman K, et al.
Front Public Health
. 2025 Feb;
12:1522213.
PMID: 40012581
Revising public health policy based on new data does not happen automatically. This is acutely relevant to the now undeniable evidence that many diseases develop differently between the sexes and...
3.
Afshar-Sterle S, Carli A, OKeefe R, Tse J, Fischer S, Azimpour A, et al.
Sci Signal
. 2024 Sep;
17(854):eabq4888.
PMID: 39288218
Doublecortin-like kinase 1 (DCLK1) is a proposed driver of gastric cancer (GC) that phosphorylates serine and threonine residues. Here, we showed that the kinase activity of DCLK1 orchestrated cancer cell-intrinsic...
4.
Huber A, Allam A, Dijkstra C, Thiem S, Huynh J, Poh A, et al.
Cell Rep
. 2024 Aug;
43(8):114616.
PMID: 39128004
Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations...
5.
Rehouma R, Buchert M, Chen Y
Int J Intell Syst
. 2024 Apr;
36(9):5085-5115.
PMID: 38607786
The novel coronavirus disease 2019 (COVID-19) is considered to be a significant health challenge worldwide because of its rapid human-to-human transmission, leading to a rise in the number of infected...
6.
Tran S, Juliani J, Harris T, Evangelista M, Ratcliffe J, Ellis S, et al.
Commun Biol
. 2024 Feb;
7(1):209.
PMID: 38378743
Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intestinal...
7.
Thilakasiri P, OKeefe R, To S, Chisanga D, Eissmann M, Carli A, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 37957015
Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In the context of gastric cancer, YAP1 is a biomarker for poor patient prognosis. Although genomic...
8.
OKeefe R, Carli A, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, et al.
Nat Commun
. 2023 Oct;
14(1):6872.
PMID: 37898600
Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type...
9.
Tse J, OKeefe R, Rigopolous A, Carli A, Waaler J, Krauss S, et al.
Biomedicines
. 2023 Oct;
11(10).
PMID: 37893093
Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and tissue homeostasis in the adult, with mutations in this pathway frequently occurring in cancer. Excessive WNT/β-catenin activity inhibits murine anterior...
10.
Halawani R, Buchert M, Chen Y
Comput Biol Med
. 2023 Jul;
164:107274.
PMID: 37506451
Tumour heterogeneity is one of the critical confounding aspects in decoding tumour growth. Malignant cells display variations in their gene transcription profiles and mutation spectra even when originating from a...