Michael B Elowitz
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Explore the profile of Michael B Elowitz including associated specialties, affiliations and a list of published articles.
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97
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10007
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Recent Articles
1.
Parres-Gold J, Levine M, Emert B, Stuart A, Elowitz M
Cell
. 2025 Feb;
PMID: 39978343
Many biological signaling pathways employ proteins that competitively dimerize in diverse combinations. These dimerization networks can perform biochemical computations in which the concentrations of monomer inputs determine the concentrations of...
2.
Kuintzle R, Santat L, Elowitz M
Elife
. 2025 Jan;
12.
PMID: 39751380
The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a...
3.
Chen Z, Linton J, Xia S, Fan X, Yu D, Wang J, et al.
Science
. 2024 Dec;
386(6727):1243-1250.
PMID: 39666795
Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de novo-designed protein heterodimers and engineered...
4.
Askary A, Chen W, Choi J, Du L, Elowitz M, Gagnon J, et al.
Nat Rev Genet
. 2024 Nov;
26(3):203-222.
PMID: 39587306
A paradigm for biology is emerging in which cells can be genetically programmed to write their histories into their own genomes. These records can subsequently be read, and the cellular...
5.
Troyer Z, Gololobova O, Koppula A, Liao Z, Horns F, Elowitz M, et al.
ACS Nano
. 2024 Sep;
18(39):26568-26584.
PMID: 39306763
The individual detection of human immunodeficiency virus (HIV) virions and resolution from extracellular vesicles (EVs) during analysis is a difficult challenge. Infectious enveloped virions and nonviral EVs are released simultaneously...
6.
Hadas R, Rubinstein H, Mittnenzweig M, Mayshar Y, Ben-Yair R, Cheng S, et al.
Nature
. 2024 Sep;
634(8034):652-661.
PMID: 39294373
The developing placenta, which in mice originates through the extraembryonic ectoderm (ExE), is essential for mammalian embryonic development. Yet unbiased characterization of the differentiation dynamics of the ExE and its...
7.
Xia S, Lu A, Tobin V, Luo K, Moeller L, Shon D, et al.
Cell
. 2024 Apr;
187(11):2785-2800.e16.
PMID: 38657604
Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate harmful cells and modulate the immune system by dampening or stimulating inflammation. Synthetic protein circuits capable...
8.
Du R, Flynn M, Honsa M, Jungmann R, Elowitz M
bioRxiv
. 2024 Apr;
PMID: 38559239
The ability to express transgenes at specified levels is critical for understanding cellular behaviors, and for applications in gene and cell therapy. Transfection, viral vectors, and other gene delivery methods...
9.
Flynn M, Mayfield A, Du R, Gradinaru V, Elowitz M
bioRxiv
. 2024 Apr;
PMID: 38559034
A longstanding challenge in gene therapy is expressing a dosage-sensitive gene within a tight therapeutic window. For example, loss of function causes Rett syndrome, while its duplication causes duplication syndrome....
10.
Tran M, Askary A, Elowitz M
Dev Cell
. 2024 Feb;
59(6):812-826.e3.
PMID: 38359830
In multicellular organisms, cell types must be produced and maintained in appropriate proportions. One way this is achieved is through committed progenitor cells or extrinsic interactions that produce specific patterns...