Michael B Elowitz
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Explore the profile of Michael B Elowitz including associated specialties, affiliations and a list of published articles.
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97
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10007
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Recent Articles
11.
Granados A, Kanrar N, Elowitz M
Cell Genom
. 2024 Jan;
4(1):100463.
PMID: 38216284
In animal cells, molecular pathways often comprise families of variant components, such as ligands or receptors. These pathway components are differentially expressed by different cell types, potentially tailoring pathway function...
12.
Parres-Gold J, Levine M, Emert B, Stuart A, Elowitz M
bioRxiv
. 2023 Nov;
PMID: 37961250
Many biological signaling pathways employ proteins that competitively dimerize in diverse combinations. These dimerization networks can perform biochemical computations, in which the concentrations of monomers (inputs) determine the concentrations of...
13.
Kuintzle R, Santat L, Elowitz M
bioRxiv
. 2023 Sep;
PMID: 37662208
The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a...
14.
Ma Y, Budde M, Zhu J, Elowitz M
ACS Synth Biol
. 2023 Aug;
12(9):2536-2545.
PMID: 37572041
Methylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific...
15.
Horns F, Martinez J, Fan C, Haque M, Linton J, Tobin V, et al.
Cell
. 2023 Jul;
186(17):3642-3658.e32.
PMID: 37437570
A system for programmable export of RNA molecules from living cells would enable both non-destructive monitoring of cell dynamics and engineering of cells capable of delivering executable RNA programs to...
16.
Zhu R, Santat L, Markson J, Nandagopal N, Gregrowicz J, Elowitz M
Sci Adv
. 2023 Jul;
9(28):eadf9336.
PMID: 37436981
Developing tissues form spatial patterns by establishing concentration gradients of diffusible signaling proteins called morphogens. The bone morphogenetic protein (BMP) morphogen pathway uses a family of extracellular modulators to reshape...
17.
Ma Y, Budde M, Zhu J, Elowitz M
bioRxiv
. 2023 Jul;
PMID: 37398290
Methylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific...
18.
Klumpe H, Garcia-Ojalvo J, Elowitz M, Antebi Y
Cell Syst
. 2023 Jun;
14(6):430-446.
PMID: 37348461
Many biological circuits comprise sets of protein variants that interact with one another in a many-to-many, or promiscuous, fashion. These architectures can provide powerful computational capabilities that are especially critical...
19.
Tran M, Askary A, Elowitz M
bioRxiv
. 2023 Jun;
PMID: 37333085
In multicellular organisms, cell types must be produced and maintained in appropriate proportions. One way this is achieved is through committed progenitor cells that produce specific sets of descendant cell...
20.
Kong Q, Xia S, Pan X, Ye K, Li Z, Li H, et al.
Sci Immunol
. 2023 Apr;
8(82):eadg3196.
PMID: 37115914
Granzyme A from killer lymphocytes cleaves gasdermin B (GSDMB) and triggers pyroptosis in targeted human tumor cells, eliciting antitumor immunity. However, GSDMB has a controversial role in pyroptosis and has...