Michael A Trembley
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Explore the profile of Michael A Trembley including associated specialties, affiliations and a list of published articles.
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22
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534
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Recent Articles
11.
Zhou P, Zhang Y, Sethi I, Ye L, Trembley M, Cao Y, et al.
Circ Res
. 2022 Oct;
131(11):e152-e168.
PMID: 36263775
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupancy in the developing heart...
12.
Quijada P, Trembley M, Misra A, Myers J, Baker C, Perez-Hernandez M, et al.
Nat Commun
. 2021 Jul;
12(1):4155.
PMID: 34230480
The organization of an integrated coronary vasculature requires the specification of immature endothelial cells (ECs) into arterial and venous fates based on their localization within the heart. It remains unclear...
13.
Guo Y, Cao Y, Jardin B, Sethi I, Ma Q, Moghadaszadeh B, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
118(2).
PMID: 33361330
The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that occur...
14.
Quijada P, Trembley M, Small E
Circ Res
. 2020 Jan;
126(3):377-394.
PMID: 31999538
The heart is lined by a single layer of mesothelial cells called the epicardium that provides important cellular contributions for embryonic heart formation. The epicardium harbors a population of progenitor...
15.
Brand C, Lighthouse J, Trembley M
J Mol Cell Cardiol
. 2019 May;
132:1-12.
PMID: 31042488
Heart failure is the leading cause of morbidity and mortality worldwide. Several lines of evidence suggest that physical activity and exercise can pre-condition the heart to improve the response to...
16.
Austin K, Trembley M, Chandler S, Sanders S, Saffitz J, Abrams D, et al.
Nat Rev Cardiol
. 2019 Apr;
16(9):519-537.
PMID: 31028357
Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial tissue. Mutations in genes that encode components of desmosomes, the...
17.
Chi C, Leonard A, Knight W, Beussman K, Zhao Y, Cao Y, et al.
Proc Natl Acad Sci U S A
. 2018 Dec;
116(2):556-565.
PMID: 30584088
Mutations in lysosomal-associated membrane protein 2 () gene are associated with Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined mechanisms. Here, we identify the LAMP-2 isoform B...
18.
Trembley M, Quijada P, Agullo-Pascual E, Tylock K, Colpan M, Dirkx Jr R, et al.
Circulation
. 2018 May;
138(17):1864-1878.
PMID: 29716942
Background: Hypertrophic cardiomyocyte growth and dysfunction accompany various forms of heart disease. The mechanisms responsible for transcriptional changes that affect cardiac physiology and the transition to heart failure are not...
19.
Cao J, Wang J, Jackman C, Cox A, Trembley M, Balowski J, et al.
Dev Cell
. 2017 Sep;
42(6):600-615.e4.
PMID: 28950101
Mechanisms that control cell-cycle dynamics during tissue regeneration require elucidation. Here we find in zebrafish that regeneration of the epicardium, the mesothelial covering of the heart, is mediated by two...
20.
Trembley M, Berrus H, Whicher J, Humphrey-Dixon E
Biosci Rep
. 2016 Dec;
34(2).
PMID: 27919033
14-3-3 proteins are highly conserved and have been found in all eukaryotic organisms investigated. They are involved in many varied cellular processes, and interact with hundreds of other proteins. Among...